Eukaryotic ribosome assembly, transport and quality control.

Peña C; Hurt E; Panse VG

doi:10.1038/nsmb.3454

Back

Journal article

Eukaryotic ribosome assembly, transport and quality control.

Peña C Institute of Biochemistry, ETH Zurich, Zurich, Switzerland.
Hurt E Biochemie Zentrum Heidelberg, University of Heidelberg, Heidelberg, Germany.
Panse VG Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland.

2017-09-08

Published in:

Nature structural & molecular biology. - 2017

English Eukaryotic ribosome synthesis is a complex, energy-consuming process that takes place across the nucleolus, nucleoplasm and cytoplasm and requires more than 200 conserved assembly factors. Here, we discuss mechanisms by which the ribosome assembly and nucleocytoplasmic transport machineries collaborate to produce functional ribosomes. We also highlight recent cryo-EM studies that provided unprecedented snapshots of ribosomes during assembly and quality control.

Language