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Journal article

Centriole assembly at a glance.

  • Gönczy P Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology (EPFL), CH-1015 Lausanne, Switzerland pierre.gonczy@epfl.ch.
  • Hatzopoulos GN Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology (EPFL), CH-1015 Lausanne, Switzerland.
  • 2019-02-22
Published in:
  • Journal of cell science. - 2019
Centriole
Centrosome
Microtubules
PLK4
SAS-6
STIL
Animals
Cell Cycle Proteins
Centrioles
Embryo, Mammalian
Eukaryotic Cells
Gene Expression Regulation
Humans
Intracellular Signaling Peptides and Proteins
Marsileaceae
Mice
Microtubules
Mitosis
Naegleria
Organelle Biogenesis
Protein-Serine-Threonine Kinases
Signal Transduction
English The centriole organelle consists of microtubules (MTs) that exhibit a striking 9-fold radial symmetry. Centrioles play fundamental roles across eukaryotes, notably in cell signaling, motility and division. In this Cell Science at a Glance article and accompanying poster, we cover the cellular life cycle of this organelle - from assembly to disappearance - focusing on human centrioles. The journey begins at the end of mitosis when centriole pairs disengage and the newly formed centrioles mature to begin a new duplication cycle. Selection of a single site of procentriole emergence through focusing of polo-like kinase 4 (PLK4) and the resulting assembly of spindle assembly abnormal protein 6 (SAS-6) into a cartwheel element are evoked next. Subsequently, we cover the recruitment of peripheral components that include the pinhead structure, MTs and the MT-connecting A-C linker. The function of centrioles in recruiting pericentriolar material (PCM) and in forming the template of the axoneme are then introduced, followed by a mention of circumstances in which centrioles form de novo or are eliminated.
Language
  • English
Open access status
bronze
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Persistent URL
https://sonar.ch/global/documents/156284
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