Journal article
Histamine receptors are hot in immunopharmacology.
- 2006-02-02
Published in:
- European journal of pharmacology. - 2006
Animals
Anti-Allergic Agents
Anti-Inflammatory Agents
Antibody Formation
B-Lymphocytes
Bronchial Hyperreactivity
Bronchoconstriction
Clinical Trials as Topic
Dendritic Cells
Histamine
Histamine H1 Antagonists, Non-Sedating
Humans
Immune Tolerance
Inflammation
Myocytes, Smooth Muscle
Receptors, Histamine
Respiratory Hypersensitivity
Signal Transduction
T-Lymphocytes
English
In addition to its well-characterized effects in the acute allergic inflammatory responses, histamine has been demonstrated to affect chronic inflammation and regulate several essential events in the immune response. Histamine can selectively recruit the major effector cells into tissue sites and affect their maturation, activation, polarization, and other functions leading to chronic inflammation. Histamine also regulates dendritic cells, T cells and B cells, as well as related antibody isotype responses. In addition, acting through its receptor 2, histamine positively interferes with the peripheral antigen tolerance induced by T regulatory cells in several pathways. The diverse effects of histamine on immune regulation appear to be due to differential expression and regulation of 4 types of histamine receptors and their distinct intracellular signals. In addition, differences in affinities of these receptors for histamine is highly decisive for the biological effects of histamine and drugs that target histamine receptors. This article highlights recent discoveries in histamine immunobiology and discusses their relevance in allergic inflammation.
- Language
-
- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/j.ejphar.2005.12.044
- PMID 16448645
- Persistent URL
- https://sonar.ch/global/documents/156373
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