Cytoskeleton-associated antigens from African trypanosomes are recognized by self-reactive antibodies of uninfected mice.
- Müller N Institut für Allgemeine Mikrobiologie, University of Bern, Switzerland.
- Imboden M
- Detmer E
- Mansfield JM
- Seebeck T
- 1993-11-01
Published in:
- Parasitology. - 1993
Animals
Antibodies, Protozoan
Antibody Formation
Antigens, Protozoan
Autoantibodies
Cross Reactions
Cytoskeletal Proteins
Epitopes
Flagella
Fluorescent Antibody Technique
Germ-Free Life
Immunoglobulin G
Immunoglobulin M
Mice
Mice, Inbred Strains
Microtubule-Associated Proteins
Protozoan Proteins
Trypanosoma brucei rhodesiense
Trypanosomiasis, African
English
Serum from uninfected mice of different strains, as well as from germ-free animals, contains antibodies which react specifically with at least two trypanosomal proteins, I/6 and MARP1. These antibody populations are highly specific for the respective proteins, are of similar affinity as hyperimmune antibodies, and consist of IgM as well as IgG isotypes. Hyperimmune antibody raised against the cross-reacting trypanosomal protein I/6 detects a 60 kDa protein in mouse 3T6 cells, which is a component of the fibroblast cytoskeleton.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1017/s0031182000067767
- PMID 7506406
- Persistent URL
- https://sonar.ch/global/documents/157506
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