Urinary 8-OHdG as a Biomarker for Oxidative Stress: A Systematic Literature Review and Meta-Analysis.
- Graille M Center for Primary Care and Public Health (Unisanté), University of Lausanne, Route de la Corniche, 21066 Epalinges-Lausanne, Switzerland.
- Wild P Center for Primary Care and Public Health (Unisanté), University of Lausanne, Route de la Corniche, 21066 Epalinges-Lausanne, Switzerland.
- Sauvain JJ Center for Primary Care and Public Health (Unisanté), University of Lausanne, Route de la Corniche, 21066 Epalinges-Lausanne, Switzerland.
- Hemmendinger M Center for Primary Care and Public Health (Unisanté), University of Lausanne, Route de la Corniche, 21066 Epalinges-Lausanne, Switzerland.
- Guseva Canu I Center for Primary Care and Public Health (Unisanté), University of Lausanne, Route de la Corniche, 21066 Epalinges-Lausanne, Switzerland.
- Hopf NB Center for Primary Care and Public Health (Unisanté), University of Lausanne, Route de la Corniche, 21066 Epalinges-Lausanne, Switzerland.
- 2020-05-30
Published in:
- International journal of molecular sciences. - 2020
English
Oxidative stress reflects a disturbance in the balance between the production and accumulation of reactive oxygen species (ROS). ROS are scavenged by the antioxidant system, but when in excess concentration, they can oxidize proteins, lipids, and DNA. DNA damage is usually repaired, and the oxidized products are excreted in urine. 8-hydroxy-2-deoxyguanosine is considered a biomarker for oxidative damage of DNA. It is needed to define background ranges for 8-OHdG, to use it as a measure of oxidative stress overproduction. We established a standardized protocol for a systematic review and meta-analysis to assess background ranges for urinary 8-OHdG concentrations in healthy populations. We computed geometric mean (GM) and geometric standard deviations (GSD) as the basis for the meta-analysis. We retrieved an initial 1246 articles, included 84 articles, and identified 128 study subgroups. We stratified the subgroups by body mass index, gender, and smoking status reported. The pooled GM value for urinary 8-OHdG concentrations in healthy adults with a mean body mass index (BMI) ≤ 25 measured using chemical methods was 3.9 ng/mg creatinine (interquartile range (IQR): 3 to 5.5 ng/mg creatinine). A significant positive association was observed between smoking and urinary 8-OHdG concentrations when measured by chemical analysis. No gender effect was observed.
- Language
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- English
- Open access status
- gold
- Identifiers
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- DOI 10.3390/ijms21113743
- PMID 32466448
- Persistent URL
- https://sonar.ch/global/documents/158893
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