Structure of the BoNT/A1--receptor complex.

Benoit RM; Frey D; Wieser MM; Thieltges KM; Jaussi R; Capitani G; Kammerer RA

doi:10.1016/j.toxicon.2015.08.002

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Journal article

Structure of the BoNT/A1--receptor complex.

Benoit RM Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institute, CH-5232 Villigen PSI, Switzerland.
Frey D Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institute, CH-5232 Villigen PSI, Switzerland.
Wieser MM Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institute, CH-5232 Villigen PSI, Switzerland.
Thieltges KM Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institute, CH-5232 Villigen PSI, Switzerland.
Jaussi R Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institute, CH-5232 Villigen PSI, Switzerland.
Capitani G Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institute, CH-5232 Villigen PSI, Switzerland.
Kammerer RA Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institute, CH-5232 Villigen PSI, Switzerland. Electronic address: richard.kammerer@psi.ch.

2015-08-12

Published in:

Toxicon : official journal of the International Society on Toxinology. - 2015

English Botulinum neurotoxin A causes botulism but is also used for medical and cosmetic applications. A detailed molecular understanding of BoNT/A--host receptor interactions is therefore fundamental for improving current clinical applications and for developing new medical strategies targeting human disorders. Towards this end, we recently solved an X-ray crystal structure of BoNT/A1 in complex with its neuronal protein receptor SV2C. Based on our findings, we discuss the potential implications for BoNT/A function.

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