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Microtubule minus-end regulation at a glance.

  • Akhmanova A Cell Biology, Department of Biology, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands a.akhmanova@uu.nl michel.steinmetz@psi.ch.
  • Steinmetz MO Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland a.akhmanova@uu.nl michel.steinmetz@psi.ch.
  • 2019-06-09
Published in:
  • Journal of cell science. - 2019
CAMSAP
Centrosome
Dynein
Gamma-tubulin ring complex
Microtubule
Spindle pole
Animals
Cell Nucleus
Centrosome
Golgi Apparatus
Humans
Microtubule-Associated Proteins
Microtubule-Organizing Center
Microtubules
Spindle Poles
English Microtubules are cytoskeletal filaments essential for numerous aspects of cell physiology. They are polarized polymeric tubes with a fast growing plus end and a slow growing minus end. In this Cell Science at a Glance article and the accompanying poster, we review the current knowledge on the dynamics and organization of microtubule minus ends. Several factors, including the γ-tubulin ring complex, CAMSAP/Patronin, ASPM/Asp, SPIRAL2 (in plants) and the KANSL complex recognize microtubule minus ends and regulate their nucleation, stability and interactions with partners, such as microtubule severing enzymes, microtubule depolymerases and protein scaffolds. Together with minus-end-directed motors, these microtubule minus-end targeting proteins (-TIPs) also control the formation of microtubule-organizing centers, such as centrosomes and spindle poles, and mediate microtubule attachment to cellular membrane structures, including the cell cortex, Golgi complex and the cell nucleus. Structural and functional studies are starting to reveal the molecular mechanisms by which dynamic -TIP networks control microtubule minus ends.
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  • English
Open access status
bronze
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Persistent URL
https://sonar.ch/global/documents/159460
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