Expression of the Escherichia coli Ada Regulon in Stationary Phase: Evidence for rpoS-Dependent Negative Regulation of alkA Transcription
- Landini, Paolo School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom2
- Busby, Stephen J. W. School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom2
Published in:
- Journal of Bacteriology. - American Society for Microbiology. - 1999, vol. 181, no. 21, p. 6836-6839
English
ABSTRACT
The Escherichia coli Ada protein activates ς70 -dependent transcription at three different promoters (ada , aidB , and alkA ) in response to alkylation damage of DNA. During stationary phase, however, the methylated form of Ada shuts off expression of alkA ; this repression is specific for ςS -dependent transcription. Thus, at the alkA promoter, the Ada protein can act as both a positive and negative modulator of the adaptive response to alkylation damage, depending on the cell’s physiological state.
- Language
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- English
- Open access status
- bronze
- Identifiers
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- DOI 10.1128/jb.181.21.6836-6839.1999
- ISSN 1098-5530
- Persistent URL
- https://sonar.ch/global/documents/159667
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