European academy of dermatology and venereology European prurigo project: expert consensus on the definition, classification and terminology of chronic prurigo.
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Pereira MP
Department of Dermatology, Competence Center for Chronic Pruritus, University Hospital Münster, Münster, Germany.
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Steinke S
Department of Dermatology, Competence Center for Chronic Pruritus, University Hospital Münster, Münster, Germany.
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Zeidler C
Department of Dermatology, Competence Center for Chronic Pruritus, University Hospital Münster, Münster, Germany.
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Forner C
Department of Dermatology, Competence Center for Chronic Pruritus, University Hospital Münster, Münster, Germany.
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Riepe C
Department of Dermatology, Competence Center for Chronic Pruritus, University Hospital Münster, Münster, Germany.
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Augustin M
Competence Center for Healthcare Research in Dermatology (CVderm), Institute for Healthcare Research in Dermatology and Nursing (IVDP), University Hospital of Hamburg-Eppendorf, Hamburg, Germany.
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Bobko S
Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology, Moscow, Russia.
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Dalgard F
Department of Dermatology and Venereology, Skåne University Hospital, Lund University, Malmö, Sweden.
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Elberling J
Department of Dermatology, University Hospital Gentofte, Copenhagen, Denmark.
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Garcovich S
Institute of Dermatology, Catholic University of the Sacred Heart, Rome, Italy.
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Gieler U
Justus Liebig University, Giessen, Germany.
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Gonçalo M
Department of Dermatology, University Hospital and Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
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Halvorsen JA
Department of Dermatology, Oslo University Hospital, University of Oslo, Oslo, Norway.
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Leslie TA
Department of Dermatology, Royal Free Hospital, London, UK.
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Metz M
Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany.
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Reich A
Department of Dermatology, University of Rzeszow, Rzeszow, Poland.
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Şavk E
Department of Dermatology, Adnan Menderes University, Aydın, Turkey.
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Schneider G
Department of Psychosomatics and Psychotherapy, Münster University Hospital, Münster, Germany.
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Serra-Baldrich E
Department of Dermatology, Cutaneous Allergy Unit, Hospital Sant Pau, Universitat Autònoma Barcelona, Barcelona, Spain.
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Ständer HF
Dermatological Practice, Bad Bentheim and Department of Dermatology, Klinikum Dortmund GmbH, Dortmund, Germany.
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Streit M
Department of Dermatology, Kantonsspital Aarau, Aarau, Switzerland.
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Wallengren J
Department of Dermatology and Venereology, Skåne University Hospital SUS Lund, Lund University, Lund, Sweden.
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Weller K
Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany.
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Wollenberg A
Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany.
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Bruland P
Institute of Medical Informatics, University of Münster, Münster, Germany.
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Soto-Rey I
Institute of Medical Informatics, University of Münster, Münster, Germany.
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Storck M
Institute of Medical Informatics, University of Münster, Münster, Germany.
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Dugas M
Institute of Medical Informatics, University of Münster, Münster, Germany.
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Weisshaar E
Department of Social Medicine, Occupational and Environmental Dermatology, University of Heidelberg, Heidelberg, Germany.
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Szepietowski JC
Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland.
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Legat FJ
Department of Dermatology, Medical University of Graz, Graz, Austria.
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Ständer S
Department of Dermatology, Competence Center for Chronic Pruritus, University Hospital Münster, Münster, Germany.
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Published in:
- Journal of the European Academy of Dermatology and Venereology : JEADV. - 2018
English
BACKGROUND
The term prurigo has been used for many decades in dermatology without clear definition, and currently used terminology of prurigo is inconsistent and confusing. Especially, itch-related prurigo remains unexplored regarding the epidemiology, clinical profile, natural course, underlying causes, available treatments and economic burden, although burdensome and difficult to treat.
OBJECTIVE
To address these issues, the multicentre European Prurigo Project (EPP) was designed to increase knowledge on chronic prurigo (CPG). In the first step, European experts of the EADV Task Force Pruritus (TFP) aimed to achieve a consensus on the definition, classification and terminology of CPG. Additionally, procedures of the cross-sectional EPP were discussed and agreed upon.
METHODS
Discussions and surveys between members of the TFP served as basis for a consensus conference. Using the Delphi method, consensus was defined as an agreement ≥75% among the present members.
RESULTS
Twenty-four members of the TFP participated in the consensus conference. Experts consented that CPG should be used as an umbrella term for the range of clinical manifestations (e.g. papular, nodular, plaque or umbilicated types). CPG is considered a distinct disease defined by the presence of chronic pruritus for ≥6 weeks, history and/or signs of repeated scratching and multiple localized/generalized pruriginous skin lesions (whitish or pink papules, nodules and/or plaques). CPG occurs due to a neuronal sensitization to itch and the development of an itch-scratch cycle.
CONCLUSION
This new definition and terminology of CPG should be implemented in dermatology to harmonize communication in the clinical routine, clinical trials and scientific literature. Acute/subacute forms of prurigo are separated entities, which need to be differentiated from CPG and will be discussed in a next step. In the near future, the cross-sectional EPP will provide relevant clinical data on various aspects of CPG leading to new directions in the scientific investigation of CGP.
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bronze
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https://sonar.ch/global/documents/159669
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