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Free Fatty acids and their metabolism affect function and survival of podocytes.

  • Sieber J Division of Nephrology, Massachusetts General Hospital, Harvard Medical School , Boston, MA , USA.
  • Jehle AW Molecular Nephrology, Department of Biomedicine, University Hospital Basel , Basel , Switzerland ; Transplantation Immunology and Nephrology, Department of Internal Medicine, University Hospital Basel , Basel , Switzerland.
  • 2014-11-12
Published in:
  • Frontiers in endocrinology. - 2014
diabetic nephropathy
endoplasmic reticulum stress
lipid metabolism
lipotoxicity
podocyte
saturated and monounsaturated free fatty acids
β-oxidation
English Podocyte injury and loss critically contribute to the pathogenesis of proteinuric kidney diseases including diabetic nephropathy. Deregulated lipid metabolism with disturbed free fatty acid (FFA) metabolism is a characteristic of metabolically unhealthy obesity and type 2 diabetes and likely contributes to end-stage kidney disease irrespective of the underlying kidney disease. In the current review, we summarize recent findings related to FFAs and altered renal FFA metabolism with a special focus on podocytes. We will outline the opposing effects of saturated and monounsaturated FFAs and a particular emphasis will be given to the underlying molecular mechanisms involving insulin resistance and endoplasmic reticulum homeostasis. Finally, recent data suggesting a critical role of renal FFA metabolism to adapt to an altered lipid environment will be discussed.
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  • English
Open access status
gold
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https://sonar.ch/global/documents/159775
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