Higher retinal vessel oxygen saturation: investigating its relationship with macular oedema in retinitis pigmentosa patients.
- Bojinova RI Department of Ophthalmology, University of Basel, Mittlere Strasse 91, Basel, CH-4031, Switzerland.
- Schorderet DF IRO-Institute for Research in Ophthalmology, Sion, Switzerland.
- Valmaggia C Department of Ophthalmology, Cantonal Hospital, St. Gallen, Switzerland.
- Türksever C Department of Ophthalmology, University of Basel, Mittlere Strasse 91, Basel, CH-4031, Switzerland.
- Schoetzau A Department of Ophthalmology, University of Basel, Mittlere Strasse 91, Basel, CH-4031, Switzerland.
- Todorova MG Department of Ophthalmology, University of Basel, Mittlere Strasse 91, Basel, CH-4031, Switzerland. margarita.todorova@usb.ch.
- 2018-03-07
Published in:
- Eye (London, England). - 2018
Adult
Case-Control Studies
Cross-Sectional Studies
Electroretinography
Female
Humans
Macular Edema
Male
Middle Aged
Oximetry
Oxygen
Prospective Studies
Regression Analysis
Retina
Retinal Vessels
Retinitis Pigmentosa
Tomography, Optical Coherence
Visual Acuity
Young Adult
English
PURPOSE
Primary objective-to investigate the effect of retinal vessel oxygen saturation (SO2) on macular oedema (ME) in retinitis pigmentosa (RP) patients. Secondary objective-to link the presence of ME to metabolic (oxygen saturation of retinal vessels, SO2), functional (multifocal electroretinography, mfERG) and structural (Spectral Domain Optical Coherent Tomography, SD-OCT) alterations in RP.
DESIGN
Prospective, cross-sectional, non-interventional study.
SUBJECTS
Patients with typical RP (N = 37) and controls (N = 19), who underwent retinal vessel Oximetry (RO), SD-OCT and mfERG, were included.
METHODS
A computer-based program of the retinal vessel analyser unit (IMEDOS Systems UG, Jena, Germany) was used to measure SO2. We evaluated the mean SO2, in all major retinal arterioles (oxygen saturation in retinal arterioles, A-SO2, %) and venules (oxygen saturation in retinal venules, V-SO2, %). MfERG responses were averaged in zones (zone 1 (0-3°), zone 2 (3-8°) and zone 3 (8-15°)) and compared to corresponding areas of the OCT. The effect of ME on SO2 was evaluated dividing the RP in two subgroups: with clinical appearance of ME (ME-RP) and without it (no-ME-RP).
MAIN OUTCOME MEASURES
Parallel recording and juxtaposition of metabolic (SO2) to structural (OCT) and functional-(mfERG) measures. Mean ( ± SD) A-SO2 and V-SO2 were higher in no-ME-RP (96.77% (±6.31) and 59.93% (±7.76)) and even higher in the ME-RP (99.82% (±6.21) and 65.63% (±7.63)), compared to controls (93.15% (±3.76) and 53.77% (±3.70), p ≤ 0.006).
RESULTS
The subgroup ME-RP differed significantly from the subgroup no-ME-RP by increased A-SO2 and V-SO2, p ≤ 0.026. The presence of ME confirmed a different relationship between the altered SO2 and the vessel diameters, against the functional and structural parameters.
CONCLUSION
Based on our results, the presence of macular oedema indicates a tendency toward greater alteration of the metabolic function in RP patients.
Primary objective-to investigate the effect of retinal vessel oxygen saturation (SO2) on macular oedema (ME) in retinitis pigmentosa (RP) patients. Secondary objective-to link the presence of ME to metabolic (oxygen saturation of retinal vessels, SO2), functional (multifocal electroretinography, mfERG) and structural (Spectral Domain Optical Coherent Tomography, SD-OCT) alterations in RP.
DESIGN
Prospective, cross-sectional, non-interventional study.
SUBJECTS
Patients with typical RP (N = 37) and controls (N = 19), who underwent retinal vessel Oximetry (RO), SD-OCT and mfERG, were included.
METHODS
A computer-based program of the retinal vessel analyser unit (IMEDOS Systems UG, Jena, Germany) was used to measure SO2. We evaluated the mean SO2, in all major retinal arterioles (oxygen saturation in retinal arterioles, A-SO2, %) and venules (oxygen saturation in retinal venules, V-SO2, %). MfERG responses were averaged in zones (zone 1 (0-3°), zone 2 (3-8°) and zone 3 (8-15°)) and compared to corresponding areas of the OCT. The effect of ME on SO2 was evaluated dividing the RP in two subgroups: with clinical appearance of ME (ME-RP) and without it (no-ME-RP).
MAIN OUTCOME MEASURES
Parallel recording and juxtaposition of metabolic (SO2) to structural (OCT) and functional-(mfERG) measures. Mean ( ± SD) A-SO2 and V-SO2 were higher in no-ME-RP (96.77% (±6.31) and 59.93% (±7.76)) and even higher in the ME-RP (99.82% (±6.21) and 65.63% (±7.63)), compared to controls (93.15% (±3.76) and 53.77% (±3.70), p ≤ 0.006).
RESULTS
The subgroup ME-RP differed significantly from the subgroup no-ME-RP by increased A-SO2 and V-SO2, p ≤ 0.026. The presence of ME confirmed a different relationship between the altered SO2 and the vessel diameters, against the functional and structural parameters.
CONCLUSION
Based on our results, the presence of macular oedema indicates a tendency toward greater alteration of the metabolic function in RP patients.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1038/s41433-018-0043-1
- PMID 29507331
- Persistent URL
- https://sonar.ch/global/documents/160072
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