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Narcolepsy with resolution of cataplexy and persisting orexin deficiency.
Journal article

Narcolepsy with resolution of cataplexy and persisting orexin deficiency.

  • Wasserman D Sleep and Brain Plasticity Centre, Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, United Kingdom.
  • Bassetti CLA Department of Neurology, Inselspital, University of Bern, Switzerland.
  • Rosenzweig I Sleep and Brain Plasticity Centre, Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, United Kingdom.
  • 2020-05-15
Published in:
  • Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine. - 2020
Pulmonary and Respiratory Medicine
Neurology
Clinical Neurology
English Narcolepsy type 1 is a debilitating chronic neurological disorder, whose main symptoms of excessive daytime sleepiness and cataplexy may partially improve with time, but typically do not fully resolve. The irreversible loss of orexin neurons is considered to be the pivotal mechanistic link underlying the development of cataplectic attacks in narcolepsy type 1. Here we describe a case of untreated narcolepsy type 1with low cerebrospinal orexin levels (< 50 pg/mL), where cataplexy fully resolved in the first 5-6 years after disease onset, whereas excessive daytime sleepiness persisted.
Language
  • English
Open access status
closed
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Persistent URL
https://sonar.ch/global/documents/161
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