Metagenomics analysis of the virome of 300 concentrates from a Swiss platelet bank.
- Brito F Department of Genetic Medicine and Development, Faculty of Medicine of Geneva, Geneva, Switzerland.
- Cordey S Laboratory of Virology, University Hospitals of Geneva, Geneva, Switzerland.
- Delwart E Blood Systems Research Institute, San Francisco, CA, USA.
- Deng X Blood Systems Research Institute, San Francisco, CA, USA.
- Tirefort D Department of Internal Medicine of Medical Specialties, Faculty of Medicine of Geneva, Geneva, Switzerland.
- Lemoine-Chaduc C Blood Transfusion Center, University Hospitals of Geneva, Geneva, Switzerland.
- Zdobnov E Department of Genetic Medicine and Development, Faculty of Medicine of Geneva, Geneva, Switzerland.
- Lecompte T Department of Internal Medicine of Medical Specialties, Faculty of Medicine of Geneva, Geneva, Switzerland.
- Kaiser L Laboratory of Virology, University Hospitals of Geneva, Geneva, Switzerland.
- Waldvogel-Abramowski S Department of Internal Medicine of Medical Specialties, Faculty of Medicine of Geneva, Geneva, Switzerland.
- Preynat-Seauve O Department of Internal Medicine of Medical Specialties, Faculty of Medicine of Geneva, Geneva, Switzerland.
- 2018-07-20
Published in:
- Vox sanguinis. - 2018
English
BACKGROUND AND OBJECTIVES
Platelet concentrates are frequently transfused to patients with reduced immunity. An exhaustive description of their viral content is needed to prevent unwanted infection.
MATERIAL AND METHODS
To track viral sequences, a shotgun metagenomics approach was used on a bank of 300 platelets concentrates. Sequences were analysed through the diagnostics-oriented pipeline ezVIR.
RESULTS
We only observed viruses commonly described in healthy individuals.
CONCLUSION
Herein is reported the first viral landscape of a platelet concentrates bank.
Platelet concentrates are frequently transfused to patients with reduced immunity. An exhaustive description of their viral content is needed to prevent unwanted infection.
MATERIAL AND METHODS
To track viral sequences, a shotgun metagenomics approach was used on a bank of 300 platelets concentrates. Sequences were analysed through the diagnostics-oriented pipeline ezVIR.
RESULTS
We only observed viruses commonly described in healthy individuals.
CONCLUSION
Herein is reported the first viral landscape of a platelet concentrates bank.
- Language
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- English
- Open access status
- green
- Identifiers
-
- DOI 10.1111/vox.12695
- PMID 30022500
- Persistent URL
- https://sonar.ch/global/documents/161396
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