The 25-hydroxyvitamin D threshold for better health.

Bischoff-Ferrari HA

doi:10.1016/j.jsbmb.2006.12.016

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Journal article

The 25-hydroxyvitamin D threshold for better health.

Bischoff-Ferrari HA Department of Rheumatology and Institute of Physical Medicine, University Hospital Zurich, Gloriastrasse 25, 8091 Zurich, Switzerland. Heiki.Bischoff@usz.ch

2007-01-18

Published in:

The Journal of steroid biochemistry and molecular biology. - 2007

English Available data supporting a target serum level of at least 75 nmol/l 25-hydroxyvitamin D (25-OHD) include studies on bone mineral density (bmd), fracture prevention, lower extremity function, and cancer prevention. Given the high cost and disability from falls, fractures, and cancer treatment a shared threshold for 25-OHD has significant public health implications, especially so, if a large part of the population is below this threshold. This article summarizes available evidence supporting the 75 nmol/l threshold, reviews adherence to Vitamin D treatment in fracture trials in regard to achieved anti-fracture efficacy, and finally discusses current recommendations for Vitamin D intake.

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