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Journal article

DNA repair nucleases.

  • Marti TM Institute of Cell Biology, University of Bern, Baltzerstrasse 4, 3012 Bern, Switzerland.
  • Fleck O
  • 2004-02-11
Published in:
  • Cellular and molecular life sciences : CMLS. - 2004
Bacterial Proteins
DNA
DNA Damage
DNA Repair
DNA Repair Enzymes
DNA Replication
Deoxyribonucleases
Fungal Proteins
Humans
Nucleic Acid Conformation
English Stability of DNA largely depends on accuracy of repair mechanisms, which remove structural anomalies induced by exogenous and endogenous agents or introduced by DNA metabolism, such as replication. Most repair mechanisms include nucleolytic processing of DNA, where nucleases cleave a phosphodiester bond between a deoxyribose and a phosphate residue, thereby producing 5'-terminal phosphate and 3'-terminal hydroxyl groups. Exonucleases hydrolyse nucleotides from either the 5' or 3' end of DNA, while endonucleases incise internal sites of DNA. Flap endonucleases cleave DNA flap structures at or near the junction between single-stranded and double-stranded regions. DNA nucleases play a crucial role in mismatch repair, nucleotide excision repair, base excision repair and double-strand break repair. In addition, nucleolytic repair functions are required during replication to remove misincorporated nucleotides, Okazaki fragments and 3' tails that may be formed after repair of stalled replication forks.
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  • English
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green
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https://sonar.ch/global/documents/162396
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