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Synthesis, characterisation and biological properties of gold(III) compounds with modified bipyridine and bipyridylamine ligands.
Journal article

Synthesis, characterisation and biological properties of gold(III) compounds with modified bipyridine and bipyridylamine ligands.

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  • 2010-02-18
Published in:
  • Dalton transactions (Cambridge, England : 2003). - 2010
Amines
Antineoplastic Agents
Cell Line, Tumor
Cell Proliferation
Crystallography, X-Ray
Drug Screening Assays, Antitumor
Gold
Humans
Ligands
Magnetic Resonance Spectroscopy
Mass Spectrometry
Models, Molecular
Molecular Structure
Organogold Compounds
Pyridines
Structure-Activity Relationship
English Square planar gold(III) complexes that contain functionalised bipyridine ligands of general formula [Au(N--N)Cl(2)][PF(6)] [where N--N = 2,2'-bipyridine, 4,4'-dimethyl-2,2'-bipyridine, 4,4'-dimethoxy-2,2'-bipyridine and 4,4'-diamino-2,2'-bipyridine] have been prepared and characterised by NMR spectroscopy and mass spectrometry. Two of the complexes have also been characterised in the solid state by X-ray crystallography. In addition, a gold(iii) compound bearing a dipyridin-2-ylamine ligand was also prepared and characterised. The complexes were found to undergo hydrolysis under pseudo-physiological conditions. Moreover, the complexes showed moderate to good cytotoxicity in vitro towards the A2780 human ovarian carcinoma cell line and the cisplatin resistant variant A2780cisR. Reactivity studies with biomolecules, such as reducing agents, plasmid DNA and a model protein (ubiquitin) were also performed to provide tentative insights into the mode of action of the complexes.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/162890
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