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Viral replication and the coactivators p300 and CBP.
Journal article

Viral replication and the coactivators p300 and CBP.

  • Hottiger MO Institute of Veterinary Biochemistry, The University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
  • Nabel GJ
  • 2000-12-15
Published in:
  • Trends in microbiology. - 2000
Animals
CREB-Binding Protein
Cell Transformation, Viral
DNA Tumor Viruses
Gene Expression Regulation, Viral
Histone Acetyltransferases
Humans
Lentivirus
Mice
Nuclear Proteins
Nuclear Receptor Coactivator 3
Trans-Activators
Virus Replication
English Productive viral infection requires coordinate regulation of viral and cellular gene expression. Viruses of different classes have evolved different mechanisms to conform to, adapt to and exploit programs of cellular gene expression. Many viral gene products influence and respond to cellular signals that control differentiation and proliferation Transcriptional coactivators are central to the regulation of the expression of genes controlling these events. p300 and CBP are closely related coactivators that regulate the transcription of specific genes, modify chromatin structure and influence cell cycle progression. In this review, the different molecular interactions of proteins encoded by DNA tumor viruses and lentiviruses with these transcriptional coactivators and related cellular proteins are summarized.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/16419
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