Journal article
Immune thrombocytopenic purpura ITP.
- 1998-08-15
Published in:
- Vox sanguinis. - 1998
Adolescent
Adult
Antigens, Human Platelet
Autoantibodies
Autoimmune Diseases
Blood Platelets
Child
Child, Preschool
Combined Modality Therapy
Female
Hemorrhagic Disorders
Humans
Immunity, Maternally-Acquired
Immunoglobulins, Intravenous
Immunologic Factors
Immunosuppressive Agents
Infant
Infant, Newborn
Infections
Interferon-alpha
Isoantibodies
Male
Phagocytosis
Pregnancy
Purpura, Thrombocytopenic, Idiopathic
Remission, Spontaneous
Splenectomy
Transfusion Reaction
English
Immune thrombocytopenic purpura ITP is characterized by early platelet destruction due to an imbalanced immune response. In acute ITP, a transient increase of HLA-DR molecules has been detected while in individuals with chronic ITP, in addition, increased serum concentrations of IL-2 and other cytokines reflecting in vivo T-cell activation have been observed. Clinically, the hemorrhagic manifestation of ITP rather than the platelet count should define the indication for active intervention. In a staging system a patient with stage III has bleeding signs and platelet counts below 10 or 20 x 10(9)/L and needs treatment, a patient with stage II should be treated on an individual level (prevention of bleeding) and a patient with stage I (no bleeding, platelet count above 50 x 10(9)/L) should be observed only.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1111/j.1423-0410.1998.tb05436.x
- PMID 9704461
- Persistent URL
- https://sonar.ch/global/documents/164831
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