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Journal article

To sprout or to split? VEGF, Notch and vascular morphogenesis.

  • 2011-11-23
Published in:
  • Biochemical Society transactions. - 2011
Animals
Blood Vessels
Cellular Microenvironment
Humans
Morphogenesis
Neovascularization, Physiologic
Receptors, Notch
Vascular Endothelial Growth Factor A
English Therapeutic angiogenesis is an attractive strategy to treat patients suffering from peripheral or coronary artery disease. VEGF (vascular endothelial growth factor-A) is the fundamental factor controlling vascular growth in both development and postnatal life. The interplay between the VEGF and Notch signalling pathway has been recently found to regulate the morphogenic events leading to the growth of new vessels by sprouting. Angiogenesis can also take place by an alternative process, i.e. intussusception or vascular splitting. However, little is known about its role in therapeutic angiogenesis and its molecular regulation. In the present article, we briefly review how VEGF dose determines the induction of normal or aberrant angiogenesis and the molecular regulation of sprouting angiogenesis by Notch signalling, and compare this process with intussusception.
Language
  • English
Open access status
green
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Persistent URL
https://sonar.ch/global/documents/165211
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