Journal article
Clinical outcomes according to diabetic status in patients treated with biodegradable polymer sirolimus-eluting stents versus durable polymer everolimus-eluting stents: prespecified subgroup analysis of the BIOSCIENCE trial.
-
Franzone A
From the Department of Cardiology, Swiss Cardiovascular Center (A.F., T.P., L.R., S.S., P.W., S.W.), Institute of Social and Preventive Medicine and Clinical Trials Unit (D.H., P. Jüni), University Hospital, Bern, Switzerland; Department of Cardiology, University Hospital, Geneva, Switzerland (M.R.); Department of Cardiology, Triemlispital, Zurich, Switzerland (D.T.); Department of Cardiology, University Hospital, Lausanne, Switzerland (A.V., O.M.); Department of Cardiology, Kantonsspital, Aarau, Switzerland (A.V.); Department of Cardiology, University Hospital, Fribourg, Switzerland (S.C.); Department of Cardiology, Kantonsspital, St. Gallen, Switzerland (D.W.); Department of Cardiology, University Hospital, Basel, Switzerland (C.K.); and Department of Cardiology, Kantonsspital, Luzern, Switzerland (P. Jamshidi).
-
Pilgrim T
From the Department of Cardiology, Swiss Cardiovascular Center (A.F., T.P., L.R., S.S., P.W., S.W.), Institute of Social and Preventive Medicine and Clinical Trials Unit (D.H., P. Jüni), University Hospital, Bern, Switzerland; Department of Cardiology, University Hospital, Geneva, Switzerland (M.R.); Department of Cardiology, Triemlispital, Zurich, Switzerland (D.T.); Department of Cardiology, University Hospital, Lausanne, Switzerland (A.V., O.M.); Department of Cardiology, Kantonsspital, Aarau, Switzerland (A.V.); Department of Cardiology, University Hospital, Fribourg, Switzerland (S.C.); Department of Cardiology, Kantonsspital, St. Gallen, Switzerland (D.W.); Department of Cardiology, University Hospital, Basel, Switzerland (C.K.); and Department of Cardiology, Kantonsspital, Luzern, Switzerland (P. Jamshidi). thomas.pilgrim@insel.ch.
-
Heg D
From the Department of Cardiology, Swiss Cardiovascular Center (A.F., T.P., L.R., S.S., P.W., S.W.), Institute of Social and Preventive Medicine and Clinical Trials Unit (D.H., P. Jüni), University Hospital, Bern, Switzerland; Department of Cardiology, University Hospital, Geneva, Switzerland (M.R.); Department of Cardiology, Triemlispital, Zurich, Switzerland (D.T.); Department of Cardiology, University Hospital, Lausanne, Switzerland (A.V., O.M.); Department of Cardiology, Kantonsspital, Aarau, Switzerland (A.V.); Department of Cardiology, University Hospital, Fribourg, Switzerland (S.C.); Department of Cardiology, Kantonsspital, St. Gallen, Switzerland (D.W.); Department of Cardiology, University Hospital, Basel, Switzerland (C.K.); and Department of Cardiology, Kantonsspital, Luzern, Switzerland (P. Jamshidi).
-
Roffi M
From the Department of Cardiology, Swiss Cardiovascular Center (A.F., T.P., L.R., S.S., P.W., S.W.), Institute of Social and Preventive Medicine and Clinical Trials Unit (D.H., P. Jüni), University Hospital, Bern, Switzerland; Department of Cardiology, University Hospital, Geneva, Switzerland (M.R.); Department of Cardiology, Triemlispital, Zurich, Switzerland (D.T.); Department of Cardiology, University Hospital, Lausanne, Switzerland (A.V., O.M.); Department of Cardiology, Kantonsspital, Aarau, Switzerland (A.V.); Department of Cardiology, University Hospital, Fribourg, Switzerland (S.C.); Department of Cardiology, Kantonsspital, St. Gallen, Switzerland (D.W.); Department of Cardiology, University Hospital, Basel, Switzerland (C.K.); and Department of Cardiology, Kantonsspital, Luzern, Switzerland (P. Jamshidi).
-
Tüller D
From the Department of Cardiology, Swiss Cardiovascular Center (A.F., T.P., L.R., S.S., P.W., S.W.), Institute of Social and Preventive Medicine and Clinical Trials Unit (D.H., P. Jüni), University Hospital, Bern, Switzerland; Department of Cardiology, University Hospital, Geneva, Switzerland (M.R.); Department of Cardiology, Triemlispital, Zurich, Switzerland (D.T.); Department of Cardiology, University Hospital, Lausanne, Switzerland (A.V., O.M.); Department of Cardiology, Kantonsspital, Aarau, Switzerland (A.V.); Department of Cardiology, University Hospital, Fribourg, Switzerland (S.C.); Department of Cardiology, Kantonsspital, St. Gallen, Switzerland (D.W.); Department of Cardiology, University Hospital, Basel, Switzerland (C.K.); and Department of Cardiology, Kantonsspital, Luzern, Switzerland (P. Jamshidi).
-
Vuilliomenet A
From the Department of Cardiology, Swiss Cardiovascular Center (A.F., T.P., L.R., S.S., P.W., S.W.), Institute of Social and Preventive Medicine and Clinical Trials Unit (D.H., P. Jüni), University Hospital, Bern, Switzerland; Department of Cardiology, University Hospital, Geneva, Switzerland (M.R.); Department of Cardiology, Triemlispital, Zurich, Switzerland (D.T.); Department of Cardiology, University Hospital, Lausanne, Switzerland (A.V., O.M.); Department of Cardiology, Kantonsspital, Aarau, Switzerland (A.V.); Department of Cardiology, University Hospital, Fribourg, Switzerland (S.C.); Department of Cardiology, Kantonsspital, St. Gallen, Switzerland (D.W.); Department of Cardiology, University Hospital, Basel, Switzerland (C.K.); and Department of Cardiology, Kantonsspital, Luzern, Switzerland (P. Jamshidi).
-
Muller O
From the Department of Cardiology, Swiss Cardiovascular Center (A.F., T.P., L.R., S.S., P.W., S.W.), Institute of Social and Preventive Medicine and Clinical Trials Unit (D.H., P. Jüni), University Hospital, Bern, Switzerland; Department of Cardiology, University Hospital, Geneva, Switzerland (M.R.); Department of Cardiology, Triemlispital, Zurich, Switzerland (D.T.); Department of Cardiology, University Hospital, Lausanne, Switzerland (A.V., O.M.); Department of Cardiology, Kantonsspital, Aarau, Switzerland (A.V.); Department of Cardiology, University Hospital, Fribourg, Switzerland (S.C.); Department of Cardiology, Kantonsspital, St. Gallen, Switzerland (D.W.); Department of Cardiology, University Hospital, Basel, Switzerland (C.K.); and Department of Cardiology, Kantonsspital, Luzern, Switzerland (P. Jamshidi).
-
Cook S
From the Department of Cardiology, Swiss Cardiovascular Center (A.F., T.P., L.R., S.S., P.W., S.W.), Institute of Social and Preventive Medicine and Clinical Trials Unit (D.H., P. Jüni), University Hospital, Bern, Switzerland; Department of Cardiology, University Hospital, Geneva, Switzerland (M.R.); Department of Cardiology, Triemlispital, Zurich, Switzerland (D.T.); Department of Cardiology, University Hospital, Lausanne, Switzerland (A.V., O.M.); Department of Cardiology, Kantonsspital, Aarau, Switzerland (A.V.); Department of Cardiology, University Hospital, Fribourg, Switzerland (S.C.); Department of Cardiology, Kantonsspital, St. Gallen, Switzerland (D.W.); Department of Cardiology, University Hospital, Basel, Switzerland (C.K.); and Department of Cardiology, Kantonsspital, Luzern, Switzerland (P. Jamshidi).
-
Weilenmann D
From the Department of Cardiology, Swiss Cardiovascular Center (A.F., T.P., L.R., S.S., P.W., S.W.), Institute of Social and Preventive Medicine and Clinical Trials Unit (D.H., P. Jüni), University Hospital, Bern, Switzerland; Department of Cardiology, University Hospital, Geneva, Switzerland (M.R.); Department of Cardiology, Triemlispital, Zurich, Switzerland (D.T.); Department of Cardiology, University Hospital, Lausanne, Switzerland (A.V., O.M.); Department of Cardiology, Kantonsspital, Aarau, Switzerland (A.V.); Department of Cardiology, University Hospital, Fribourg, Switzerland (S.C.); Department of Cardiology, Kantonsspital, St. Gallen, Switzerland (D.W.); Department of Cardiology, University Hospital, Basel, Switzerland (C.K.); and Department of Cardiology, Kantonsspital, Luzern, Switzerland (P. Jamshidi).
-
Kaiser C
From the Department of Cardiology, Swiss Cardiovascular Center (A.F., T.P., L.R., S.S., P.W., S.W.), Institute of Social and Preventive Medicine and Clinical Trials Unit (D.H., P. Jüni), University Hospital, Bern, Switzerland; Department of Cardiology, University Hospital, Geneva, Switzerland (M.R.); Department of Cardiology, Triemlispital, Zurich, Switzerland (D.T.); Department of Cardiology, University Hospital, Lausanne, Switzerland (A.V., O.M.); Department of Cardiology, Kantonsspital, Aarau, Switzerland (A.V.); Department of Cardiology, University Hospital, Fribourg, Switzerland (S.C.); Department of Cardiology, Kantonsspital, St. Gallen, Switzerland (D.W.); Department of Cardiology, University Hospital, Basel, Switzerland (C.K.); and Department of Cardiology, Kantonsspital, Luzern, Switzerland (P. Jamshidi).
-
Jamshidi P
From the Department of Cardiology, Swiss Cardiovascular Center (A.F., T.P., L.R., S.S., P.W., S.W.), Institute of Social and Preventive Medicine and Clinical Trials Unit (D.H., P. Jüni), University Hospital, Bern, Switzerland; Department of Cardiology, University Hospital, Geneva, Switzerland (M.R.); Department of Cardiology, Triemlispital, Zurich, Switzerland (D.T.); Department of Cardiology, University Hospital, Lausanne, Switzerland (A.V., O.M.); Department of Cardiology, Kantonsspital, Aarau, Switzerland (A.V.); Department of Cardiology, University Hospital, Fribourg, Switzerland (S.C.); Department of Cardiology, Kantonsspital, St. Gallen, Switzerland (D.W.); Department of Cardiology, University Hospital, Basel, Switzerland (C.K.); and Department of Cardiology, Kantonsspital, Luzern, Switzerland (P. Jamshidi).
-
Räber L
From the Department of Cardiology, Swiss Cardiovascular Center (A.F., T.P., L.R., S.S., P.W., S.W.), Institute of Social and Preventive Medicine and Clinical Trials Unit (D.H., P. Jüni), University Hospital, Bern, Switzerland; Department of Cardiology, University Hospital, Geneva, Switzerland (M.R.); Department of Cardiology, Triemlispital, Zurich, Switzerland (D.T.); Department of Cardiology, University Hospital, Lausanne, Switzerland (A.V., O.M.); Department of Cardiology, Kantonsspital, Aarau, Switzerland (A.V.); Department of Cardiology, University Hospital, Fribourg, Switzerland (S.C.); Department of Cardiology, Kantonsspital, St. Gallen, Switzerland (D.W.); Department of Cardiology, University Hospital, Basel, Switzerland (C.K.); and Department of Cardiology, Kantonsspital, Luzern, Switzerland (P. Jamshidi).
-
Stortecky S
From the Department of Cardiology, Swiss Cardiovascular Center (A.F., T.P., L.R., S.S., P.W., S.W.), Institute of Social and Preventive Medicine and Clinical Trials Unit (D.H., P. Jüni), University Hospital, Bern, Switzerland; Department of Cardiology, University Hospital, Geneva, Switzerland (M.R.); Department of Cardiology, Triemlispital, Zurich, Switzerland (D.T.); Department of Cardiology, University Hospital, Lausanne, Switzerland (A.V., O.M.); Department of Cardiology, Kantonsspital, Aarau, Switzerland (A.V.); Department of Cardiology, University Hospital, Fribourg, Switzerland (S.C.); Department of Cardiology, Kantonsspital, St. Gallen, Switzerland (D.W.); Department of Cardiology, University Hospital, Basel, Switzerland (C.K.); and Department of Cardiology, Kantonsspital, Luzern, Switzerland (P. Jamshidi).
-
Wenaweser P
From the Department of Cardiology, Swiss Cardiovascular Center (A.F., T.P., L.R., S.S., P.W., S.W.), Institute of Social and Preventive Medicine and Clinical Trials Unit (D.H., P. Jüni), University Hospital, Bern, Switzerland; Department of Cardiology, University Hospital, Geneva, Switzerland (M.R.); Department of Cardiology, Triemlispital, Zurich, Switzerland (D.T.); Department of Cardiology, University Hospital, Lausanne, Switzerland (A.V., O.M.); Department of Cardiology, Kantonsspital, Aarau, Switzerland (A.V.); Department of Cardiology, University Hospital, Fribourg, Switzerland (S.C.); Department of Cardiology, Kantonsspital, St. Gallen, Switzerland (D.W.); Department of Cardiology, University Hospital, Basel, Switzerland (C.K.); and Department of Cardiology, Kantonsspital, Luzern, Switzerland (P. Jamshidi).
-
Jüni P
From the Department of Cardiology, Swiss Cardiovascular Center (A.F., T.P., L.R., S.S., P.W., S.W.), Institute of Social and Preventive Medicine and Clinical Trials Unit (D.H., P. Jüni), University Hospital, Bern, Switzerland; Department of Cardiology, University Hospital, Geneva, Switzerland (M.R.); Department of Cardiology, Triemlispital, Zurich, Switzerland (D.T.); Department of Cardiology, University Hospital, Lausanne, Switzerland (A.V., O.M.); Department of Cardiology, Kantonsspital, Aarau, Switzerland (A.V.); Department of Cardiology, University Hospital, Fribourg, Switzerland (S.C.); Department of Cardiology, Kantonsspital, St. Gallen, Switzerland (D.W.); Department of Cardiology, University Hospital, Basel, Switzerland (C.K.); and Department of Cardiology, Kantonsspital, Luzern, Switzerland (P. Jamshidi).
-
Windecker S
From the Department of Cardiology, Swiss Cardiovascular Center (A.F., T.P., L.R., S.S., P.W., S.W.), Institute of Social and Preventive Medicine and Clinical Trials Unit (D.H., P. Jüni), University Hospital, Bern, Switzerland; Department of Cardiology, University Hospital, Geneva, Switzerland (M.R.); Department of Cardiology, Triemlispital, Zurich, Switzerland (D.T.); Department of Cardiology, University Hospital, Lausanne, Switzerland (A.V., O.M.); Department of Cardiology, Kantonsspital, Aarau, Switzerland (A.V.); Department of Cardiology, University Hospital, Fribourg, Switzerland (S.C.); Department of Cardiology, Kantonsspital, St. Gallen, Switzerland (D.W.); Department of Cardiology, University Hospital, Basel, Switzerland (C.K.); and Department of Cardiology, Kantonsspital, Luzern, Switzerland (P. Jamshidi).
Show more…
Published in:
- Circulation. Cardiovascular interventions. - 2015
English
BACKGROUND
Ultrathin strut biodegradable polymer sirolimus-eluting stents (BP-SES) proved noninferior to durable polymer everolimus-eluting stents (DP-EES) for a composite clinical end point in a population with minimal exclusion criteria. We performed a prespecified subgroup analysis of the Ultrathin Strut Biodegradable Polymer Sirolimus-Eluting Stent Versus Durable Polymer Everolimus-Eluting Stent for Percutaneous Coronary Revascularisation (BIOSCIENCE) trial to compare the performance of BP-SES and DP-EES in patients with diabetes mellitus.
METHODS AND RESULTS
BIOSCIENCE trial was an investigator-initiated, single-blind, multicentre, randomized, noninferiority trial comparing BP-SES versus DP-EES. The primary end point, target lesion failure, was a composite of cardiac death, target-vessel myocardial infarction, and clinically indicated target lesion revascularization within 12 months. Among a total of 2119 patients enrolled between February 2012 and May 2013, 486 (22.9%) had diabetes mellitus. Overall diabetic patients experienced a significantly higher risk of target lesion failure compared with patients without diabetes mellitus (10.1% versus 5.7%; hazard ratio [HR], 1.80; 95% confidence interval [CI], 1.27-2.56; P=0.001). At 1 year, there were no differences between BP-SES versus DP-EES in terms of the primary end point in both diabetic (10.9% versus 9.3%; HR, 1.19; 95% CI, 0.67-2.10; P=0.56) and nondiabetic patients (5.3% versus 6.0%; HR, 0.88; 95% CI, 0.58-1.33; P=0.55). Similarly, no significant differences in the risk of definite or probable stent thrombosis were recorded according to treatment arm in both study groups (4.0% versus 3.1%; HR, 1.30; 95% CI, 0.49-3.41; P=0.60 for diabetic patients and 2.4% versus 3.4%; HR, 0.70; 95% CI, 0.39-1.25; P=0.23, in nondiabetics).
CONCLUSIONS
In the prespecified subgroup analysis of the BIOSCIENCE trial, clinical outcomes among diabetic patients treated with BP-SES or DP-EES were comparable at 1 year.
CLINICAL TRIAL REGISTRATION
URL: http://www.clinicaltrials.gov. Unique identifier: NCT01443104.
-
Language
-
-
Open access status
-
closed
-
Identifiers
-
-
Persistent URL
-
https://sonar.ch/global/documents/166884
Statistics
Document views: 20
File downloads: