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Target-Controlled Infusion: A Mature Technology.
Journal article

Target-Controlled Infusion: A Mature Technology.

  • Absalom AR From the *Department of Anesthesiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; †Glen Pharma, Knutsford, Cheshire, United Kingdom; ‡Department of Anesthesiology, Intensive Care, Rescue and Pain Medicine, Kantonsspital St. Gallen, St. Gallen, Switzerland; §Faculty of Medicine, Anesthesiology, University of Berne, Berne, Switzerland; and ∥Department of Anesthesia, Ghent University, Gent, Belgium.
  • Glen JI
  • Zwart GJ
  • Schnider TW
  • Struys MM
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  • 2015-10-31
Published in:
  • Anesthesia and analgesia. - 2016
Anesthetics, Intravenous
Consciousness
Device Approval
Diffusion of Innovation
Drug Delivery Systems
Drug Dosage Calculations
Drug Monitoring
Equipment Design
Humans
Hypnotics and Sedatives
Infusions, Intravenous
Models, Biological
Monitoring, Intraoperative
Software
English Target-controlled infusions (TCIs) have been used in research and clinical practice for >2 decades. Nonapproved TCI software systems have been used during the conduct of almost 600 peer-reviewed published studies involving large numbers of patients. The first-generation pumps were first approved in 1996, and since then an estimated 25,000 units have been sold and used. Second-generation pumps were first approved in 2003. During 2004 to 2013, >36,000 units were sold. Currently, TCI systems are approved or available in at least 96 countries. TCI systems are used to administer propofol and opioids for IV sedation and general anesthesia for millions of patients every year. In countries where TCI systems are approved, nonapproved software is still commonly used in studies of the pharmacology of hypnotics and opioids, because research software offers greater flexibility than approved TCI systems. Research software is also readily integrated into data management modules. Although TCI is a part of established practice around the world, TCI devices have not received regulatory approval in the United States. In the United States, TCI administration of propofol and opioids for sedation and anesthesia is only possible using research software in IRB-approved research studies.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/166983
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