Symptoms of Depression and Anxiety Are Independently Associated With Clinical Recurrence of Inflammatory Bowel Disease.
- Mikocka-Walus A Department of Health Sciences, University of York, York, United Kingdom; School of Psychology, University of Adelaide, Adelaide, Australia; Foundation Brocher, Geneva, Switzerland. Electronic address: antonina.mikocka-walus@york.ac.uk.
- Pittet V Health Care Evaluation Unit, Institute of Social and Preventive Medicine, University of Lausanne, Lausanne, Switzerland.
- Rossel JB Health Care Evaluation Unit, Institute of Social and Preventive Medicine, University of Lausanne, Lausanne, Switzerland.
- von Känel R Department of Clinical Research, University of Bern, Bern, Switzerland; Department of Neurology, Inselspital, Bern University Hospital, Bern, Switzerland; Department of Psychosomatic Medicine, Clinic Barmelweid, Barmelweid, Switzerland.
- 2016-01-29
Published in:
- Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. - 2016
CD
HADS
Mental Health
UC
Adolescent
Adult
Aged
Aged, 80 and over
Anxiety
Depression
Female
Humans
Inflammatory Bowel Diseases
Male
Middle Aged
Prospective Studies
Recurrence
Severity of Illness Index
Switzerland
Young Adult
English
BACKGROUND & AIMS
We examined the relationship between symptoms of depression and anxiety and clinical recurrence of inflammatory bowel disease (IBD) in a large patient cohort. We considered the progression of depression and anxiety over time.
METHODS
We collected clinical and treatment data on 2007 adult participants of the Swiss IBD study (56% with Crohn's disease [CD], 48% male) performed in Switzerland from 2006 through 2015. Depression and anxiety symptoms were quantified by using the Hospital Anxiety and Depression Scale. The relationship between depression and anxiety scores and clinical recurrence was analyzed by using survival-time techniques.
RESULTS
We found a significant association between symptoms of depression and clinical recurrence over time (for all patients with IBD, P = .000001; for subjects with CD, P = .0007; for subjects with ulcerative colitis, P = .005). There was also a significant relationship between symptoms of anxiety and clinical recurrence over time in all subjects with IBD (P = .0014) and in subjects with CD (P = .031) but not ulcerative colitis (P = .066).
CONCLUSIONS
In an analysis of a large cohort of subjects with IBD, we found a significant association between symptoms of depression or anxiety and clinical recurrence. Patients with IBD should therefore be screened for clinically relevant levels of depression and anxiety and referred to psychologists or psychiatrists for further evaluation and treatment.
We examined the relationship between symptoms of depression and anxiety and clinical recurrence of inflammatory bowel disease (IBD) in a large patient cohort. We considered the progression of depression and anxiety over time.
METHODS
We collected clinical and treatment data on 2007 adult participants of the Swiss IBD study (56% with Crohn's disease [CD], 48% male) performed in Switzerland from 2006 through 2015. Depression and anxiety symptoms were quantified by using the Hospital Anxiety and Depression Scale. The relationship between depression and anxiety scores and clinical recurrence was analyzed by using survival-time techniques.
RESULTS
We found a significant association between symptoms of depression and clinical recurrence over time (for all patients with IBD, P = .000001; for subjects with CD, P = .0007; for subjects with ulcerative colitis, P = .005). There was also a significant relationship between symptoms of anxiety and clinical recurrence over time in all subjects with IBD (P = .0014) and in subjects with CD (P = .031) but not ulcerative colitis (P = .066).
CONCLUSIONS
In an analysis of a large cohort of subjects with IBD, we found a significant association between symptoms of depression or anxiety and clinical recurrence. Patients with IBD should therefore be screened for clinically relevant levels of depression and anxiety and referred to psychologists or psychiatrists for further evaluation and treatment.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1016/j.cgh.2015.12.045
- PMID 26820402
- Persistent URL
- https://sonar.ch/global/documents/167053
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