The Scientific Case for Brain Simulations.
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Einevoll GT
Faculty of Science and Technology, Norwegian University of Life Sciences, 1432 Ås, Norway; Department of Physics, University of Oslo, 0316 Oslo, Norway. Electronic address: gaute.einevoll@nmbu.no.
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Destexhe A
Paris-Saclay Institute of Neuroscience (NeuroPSI), Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette, France; European Institute for Theoretical Neuroscience, 75012 Paris, France.
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Diesmann M
Institute of Neuroscience and Medicine (INM-6), Institute for Advanced Simulation (IAS-6), and JARA-Institut Brain Structure-Function Relationships (INM-10), Jülich Research Centre, 52425 Jülich, Germany; Department of Psychiatry, Psychotherapy, and Psychosomatics, RWTH Aachen University, 52074 Aachen, Germany; Department of Physics, RWTH Aachen University, 52074 Aachen, Germany.
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Grün S
Institute of Neuroscience and Medicine (INM-6), Institute for Advanced Simulation (IAS-6), and JARA-Institut Brain Structure-Function Relationships (INM-10), Jülich Research Centre, 52425 Jülich, Germany; Theoretical Systems Neurobiology, RWTH Aachen University, 52074 Aachen, Germany.
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Jirsa V
Institut de Neurosciences des Systèmes (INS), INSERM, Aix Marseille Université, 13005 Marseille, France.
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de Kamps M
Institute for Artificial and Biological Intelligence, School of Computing, Leeds LS2 9JT, UK.
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Migliore M
Institute of Biophysics, National Research Council, 90146 Palermo, Italy.
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Ness TV
Faculty of Science and Technology, Norwegian University of Life Sciences, 1432 Ås, Norway.
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Plesser HE
Faculty of Science and Technology, Norwegian University of Life Sciences, 1432 Ås, Norway; Institute of Neuroscience and Medicine (INM-6), Institute for Advanced Simulation (IAS-6), and JARA-Institut Brain Structure-Function Relationships (INM-10), Jülich Research Centre, 52425 Jülich, Germany.
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Schürmann F
Blue Brain Project, École Polytechnique Fédérale de Lausanne (EPFL), Campus Biotech, 1202 Geneva, Switzerland.
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English
A key element of the European Union's Human Brain Project (HBP) and other large-scale brain research projects is the simulation of large-scale model networks of neurons. Here, we argue why such simulations will likely be indispensable for bridging the scales between the neuron and system levels in the brain, and why a set of brain simulators based on neuron models at different levels of biological detail should therefore be developed. To allow for systematic refinement of candidate network models by comparison with experiments, the simulations should be multimodal in the sense that they should predict not only action potentials, but also electric, magnetic, and optical signals measured at the population and system levels.
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Language
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Open access status
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bronze
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Persistent URL
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https://sonar.ch/global/documents/16708
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