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Endogenous multidien rhythm of epilepsy in rats.
Journal article

Endogenous multidien rhythm of epilepsy in rats.

  • Baud MO Sleep-Wake-Epilepsy Center and Center for Experimental Neurology, Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland; Wyss Center for Bio and Neuro-engineering, Geneva, Switzerland. Electronic address: maxime.baud.neuro@gmail.com.
  • Ghestem A Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France.
  • Benoliel JJ INSERM UMR-S 1124, Paris Descartes University, Sorbonne Paris Cité, 45, rue des Saints-Pères, Paris 75006, France; Service de Biochimie Endocrinienne et Oncologique, Hôpital de la Pitié-Salpêtrière, Paris, France.
  • Becker C INSERM UMR-S 1124, Paris Descartes University, Sorbonne Paris Cité, 45, rue des Saints-Pères, Paris 75006, France.
  • Bernard C Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France.
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  • 2019-02-19
Published in:
  • Experimental neurology. - 2019
Chronic EEG
Chronobiology
Circadian
Epilepsy
Multidien
Animals
Circadian Rhythm
Electroencephalography
Environment
Epilepsy, Temporal Lobe
Male
Periodicity
Rats
Rats, Sprague-Dawley
Seizures
English Recent trials of chronic EEG in humans showed that epilepsy is a cyclical disorder of the brain with rhythms at multiple time-scales: circadian, multi-day (multidien) or even seasonal. Here, we analyzed chronic EEG data (>30 days) in male epileptic rats and unraveled not only circadian but also, slower, multidien rhythms of interictal epileptiform activity with periodicity of about 2-3 and 5-7 days. Importantly, seizures were not uniformly distributed over time, but rather clustered at preferential phases of these underlying rhythms, delineating critical circadian times and multidien phase of heightened seizure risk. Multidien rhythms were not synchronous across animals or with human intervention suggesting an endogenous generator. In epilepsy, across species, unknown factors modulate seizure timing in cyclical patterns over multiple days.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/167173
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