Journal article
Are midsagittal tissue bridges predictive of outcome after cervical spinal cord injury?
- Huber E Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland.
- Lachappelle P Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland.
- Sutter R Radiology, Balgrist University Hospital, Zurich, Switzerland.
- Curt A Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland.
- Freund P Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland.
- 2017-04-11
Published in:
- Annals of neurology. - 2017
Adolescent
Adult
Aged
Biomarkers
Cervical Cord
Evoked Potentials, Motor
Evoked Potentials, Somatosensory
Female
Follow-Up Studies
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Outcome Assessment, Health Care
Prognosis
Quadriplegia
Spinal Cord Injuries
Young Adult
English
T2 -weighted scans provided data on the extent and dynamics of neuronal tissue damage and midsagittal tissue bridges at the epicenter of traumatic cervical spinal cord lesions in 24 subacute tetraplegic patients. At 1 month postinjury, smaller lesion area and midsagittal tissue bridges identified those patients with lower extremity evoked potentials and better clinical recovery. Wider midsagittal tissue bridges and smaller lesions at 1 month post-injury were associated with neurological and functional recovery at 1-year follow-up. Neuroimaging biomarkers of lesion size and midsagittal tissue bridges are potential outcome predictors and patient stratifiers in both subacute and chronic clinical trials. Ann Neurol 2017;81:740-748.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1002/ana.24932
- PMID 28393423
- Persistent URL
- https://sonar.ch/global/documents/167581
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