Back
Measurement of corticosterone in mice: a protocol for a mapping review.
Journal article

Measurement of corticosterone in mice: a protocol for a mapping review.

  • Leenaars CHC Institute for Laboratory Animal Science, Hannover Medical School, Germany.
  • van der Mierden S Institute for Laboratory Animal Science, Hannover Medical School, Germany.
  • Durst M Division of Surgical Research, University Hospital Zurich, University of Zurich, Switzerland.
  • Goerlich-Jansson VC Department of Animals in Science and Society, Utrecht University, The Netherlands.
  • Ripoli FL Institute for Laboratory Animal Science, Hannover Medical School, Germany.
  • Keubler LM Institute for Laboratory Animal Science, Hannover Medical School, Germany.
  • Talbot SR Institute for Laboratory Animal Science, Hannover Medical School, Germany.
  • Boyle E Institute for Laboratory Animal Science, Hannover Medical School, Germany.
  • Habedank A German Centre for the Protection of Laboratory Animals (Bf3R), German Federal Institute for Risk Assessment, Berlin, Germany.
  • Jirkof P Division of Surgical Research, University Hospital Zurich, University of Zurich, Switzerland.
  • Lewejohann L German Centre for the Protection of Laboratory Animals (Bf3R), German Federal Institute for Risk Assessment, Berlin, Germany.
  • Gass P Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim Faculty, Germany.
  • Tolba R Institute for Laboratory Animal Science and Experimental Surgery, RWTH Aachen University, Germany.
  • Bleich A Institute for Laboratory Animal Science, Hannover Medical School, Germany.
Show more…
  • 2019-10-29
Published in:
  • Laboratory animals. - 2020
corticosterone
detection
mapping review
mice
specimen
systematic review
Animals
Corticosterone
Mice
Milk
Saliva
Specimen Handling
Systematic Reviews as Topic
English Severity assessment for experiments conducted with laboratory animals is still based mainly on subjective evaluations; evidence-based methods are scarce. Objective measures, amongst which determination of the concentrations of stress hormones, can be used to aid severity assessment. Short-term increases in glucocorticoid concentrations generally reflect healthy responses to stressors, but prolonged increases may indicate impaired welfare. As mice are the most commonly used laboratory animal species, we performed a systematic mapping review of corticosterone measurements in Mus musculus, to provide a full overview of specimen types (e.g. blood, urine, hair, saliva, and milk) and analysis techniques. In this publication, we share our protocol and search strategy, and our rationale for performing this systematic analysis to advance severity assessment. So far, we have screened 13,520 references, and included 5337 on primary studies with measurements of endogenous corticosterone in M. musculus. Data extraction is currently in progress. When finished, this mapping review will be a valuable resource for scientists interested in corticosterone measurements to aid severity assessment. We plan to present the data in a publication and a searchable database, which will allow for even easier retrieval of the relevant literature. These resources will aid implementation of objective measures into severity assessment.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/167628
Statistics
Document views: 27 File downloads: