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Neonatal and early life vaccinology.
Journal article

Neonatal and early life vaccinology.

  • Siegrist CA WHO Collaborating Centre for Neonatal Vaccinology, Departments of Pediatrics and Pathology, University of Geneva, 1 Michel-Servet, 1211 4, Geneva, Switzerland. claire-anne.siegrist@medecine.unige.ch
  • 2001-05-12
Published in:
  • Vaccine. - 2001
Animals
Animals, Newborn
Antibody Formation
Antigen-Presenting Cells
Antigens
B-Lymphocytes
Female
Humans
Immunoglobulin G
Immunologic Memory
Infant
Infant, Newborn
Maternal-Fetal Exchange
Mice
Polysaccharides, Bacterial
Pregnancy
T-Lymphocytes
Vaccination
English Preclinical and human vaccine studies indicate that, although neonatal immunisation does not generally lead to rapid and strong antibody responses, it may result in an efficient immunological priming, which can serve as an excellent basis for future responses. The apparent impairment of CD4 and CD8 T-cell function in early life seems to result from suboptimal antigen-presenting cells-T cell interactions, which can be overcome by use of specific adjuvants or delivery systems. Although persistence of maternal antibodies may limit infant antibody responses, induction of T-cell responses largely remain unaffected by these passively transferred antibodies. Thus, neonatal priming and early boosting with vaccine formulations optimised for sufficient early life immunogenicity and maximal safety profiles, could allow better control of the huge infectious disease burden in early life.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/169077
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