Yeast RNA helicases of the DEAD-box family involved in translation initiation.

Linder P

doi:10.1016/s0248-4900(03)00032-7

Back

Journal article

Yeast RNA helicases of the DEAD-box family involved in translation initiation.

Linder P Departement de Biochimie médicale, CMU, 1, rue Michel-Servet, 1211 Geneva 4, Switzerland. patrick.linder@medecine.unige.ch

2003-07-18

Published in:

Biology of the cell. - 2003

Eukaryotic Initiation Factor-4A

Saccharomyces cerevisiae Proteins

Schizosaccharomyces pombe Proteins

English RNA helicases of the DEAD-box and related families have been found to be required for all processes involving RNA molecules. Biochemical and genetic analyses have shown that at least two RNA helicases are required for translation initiation in yeast. Although it is generally believed that these enzymes are necessary to unwind secondary structures in the 5' untranslated region of mRNAs, their exact role has not been convincingly shown. We discuss here our present knowledge of the function of eIF4A and Ded1p, two DEAD-box proteins required for translation in eukaryotic cells.

Language