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Conjugated Polyimine Dynamers as Phase-Sensitive Membrane Probes.

  • Sakai N Department of Organic Chemistry , University of Geneva , CH-1211 Geneva 4, Switzerland.
  • Matile S Department of Organic Chemistry , University of Geneva , CH-1211 Geneva 4, Switzerland.
  • 2018-08-30
Published in:
  • Journal of the American Chemical Society. - 2018
Circular Dichroism
Fluorescence
Fluorescent Dyes
Imines
Molecular Structure
Polymers
English In this report, dynamic polyimines are introduced as multifunctional sensors of lipid bilayer phases. Under mildly acidic conditions, self-condensation of push-pull amino formyl fluorenes into polyimines occurs in solid- or liquid-ordered phases but not in liquid-disordered phases of vesicular membranes. The obtained conjugated polymers are characterized by a progressive red shift of the absorption maxima, the appearance of exciton-coupled circular dichroism (CD) bands, and fluorescence quenching. These characteristics allow multiple modes of detection of membrane phases, which are known to change under membrane tension.
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  • English
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green
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https://sonar.ch/global/documents/170963
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