Journal article
Text Mining in Electronic Medical Records Enables Quick and Efficient Identification of Pregnancy Cases Occurring After Breast Cancer
- Labrosse, Julie Institut Curie, Paris, France
- Lam, Thanh Geneva University Hospitals, Geneva, Switzerland
- Sebbag, Clara Institut Curie, Paris, France
- Benque, Milena Institut Curie, Paris, France
- Abdennebi, Ines Institut Curie, Paris, France
- Merckelbagh, Hilde Port-Royal Maternity Unit, Paris, France
- Osdoit, Marie Institut Curie, Paris, France
- Priour, Maël Institut Curie, Paris, France
- Guerin, Julien Institut Curie, Paris, France
- Balezeau, Thomas Institut Curie, Paris, France
- Grandal, Beatriz Institut Curie, Paris, France
- Coussy, Florence Institut Curie, Paris, France
- Bobrie, Angélique Cancerology Institute, Montpellier, France
- Ferrer, Loïc Institut Curie, U900, Hôpital René Huguenin, Saint-Cloud, France
- Laas, Enora Institut Curie, Paris, France
- Feron, Jean-Guillaume Institut Curie, Paris, France
- Reyal, Fabien Paris 5 Research University, INSERM U932, Institut Curie, Paris, France
- Hamy, Anne-Sophie Paris 5 Research University, INSERM U932, Institut Curie, Paris, France
Published in:
- JCO Clinical Cancer Informatics. - American Society of Clinical Oncology (ASCO). - 2019, no. 3, p. 1-12
English
PURPOSE To apply text mining (TM) technology on electronic medical records (EMRs) of patients with breast cancer (BC) to retrieve the occurrence of a pregnancy after BC diagnosis and compare its performance to manual curation. MATERIALS AND METHODS The training cohort (Cohort A) comprised 344 patients with BC age ≤ 40 years old treated at Institut Curie between 2005 and 2007. Manual curation consisted in manually reviewing each EMR to retrieve pregnancies. TM consisted of first applying a keyword filter (“accouch*” or “enceinte,” French terms for “deliver*” and “pregnant,” respectively) to select a subset of EMRs, and, second, checking manually EMRs to confirm the pregnancy. Then, we applied our TM algorithm on an independent cohort of patients with BC treated between 2008 and 2012 (Cohort B). RESULTS In Cohort A, 36 pregnancies were identified among 344 patients (10.5%; 2,829 person-years of EMR). Thirty were identified by manual review versus 35 by TM. TM resulted in a lower percentage of manual checking (26.7% v 100%, respectively) and substantial time gains (time to identify a pregnancy: 13 minutes for TM v 244 minutes for manual curation, respectively). Presence of any of the two TM filters showed excellent sensitivity (97%) and negative predictive value (100%). In Cohort B, 67 pregnancies were identified among 1,226 patients (5.5%; 7,349 person-years of EMR). Similarly, for Cohort B, TM spared 904 (73.7%) EMRs from manual review and quickly generated a cohort of 67 pregnancies after BC. Incidence rate of pregnancy after BC was 0.01 pregnancy per person-year of EMR in both cohorts. CONCLUSION TM is highly efficient to quickly identify rare events and is a promising tool to improve rapidity, efficiency, and costs of medical research.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1200/cci.19.00031
- ISSN 2473-4276
- Persistent URL
- https://sonar.ch/global/documents/170969
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