Journal article
Sweat test in patients with glucose-6-phosphate-1-dehydrogenase deficiency.
- Casaulta C Department of Paediatrics, University of Berne, Switzerland.
- Stirnimann A
- Schoeni MH
- Barben J
- 2008-05-06
Published in:
- Archives of disease in childhood. - 2008
Adult
Child
Child, Preschool
Chlorides
Cystic Fibrosis
Diagnosis, Differential
Electric Conductivity
False Positive Reactions
Female
Glucosephosphate Dehydrogenase Deficiency
Humans
Infant
Male
Middle Aged
Sodium
Sweat
English
BACKGROUND
A false-positive sweat test in patients with deficiency of glucose-6-phosphate-1-dehydrogenase (EC 1.1.1.49; G6PD) is repeatedly reported.
METHODS
Sweat chloride or conductivity was measured in 11 patients with G6PD deficiency.
RESULTS
Mean (SD) chloride level (n = 8, median age 9.2 years, range 1.9-48.5) was 18.8 (9.6 mmol/l) and, mean (SD) sodium level was 26.0 (10.0 mmol/l), respectively, and mean (SD) conductivity (n = 3, median age 6.6 years, range 1.9-40.5) was 34.3 (6.5 mmol/l).
CONCLUSION
In sweat of 11 patients with G6PD deficiency we did not find any abnormality. The reason for alleged false-positive sweat test in patients with G6PD deficiency is not known and we were unable to identify any original reference. It appears that tables of putative false-positive sweat tests in several disease states have been directly "copied and pasted" from one paper or textbook to another without verifying the original literature, a phenomenon one can call "chain citation".
A false-positive sweat test in patients with deficiency of glucose-6-phosphate-1-dehydrogenase (EC 1.1.1.49; G6PD) is repeatedly reported.
METHODS
Sweat chloride or conductivity was measured in 11 patients with G6PD deficiency.
RESULTS
Mean (SD) chloride level (n = 8, median age 9.2 years, range 1.9-48.5) was 18.8 (9.6 mmol/l) and, mean (SD) sodium level was 26.0 (10.0 mmol/l), respectively, and mean (SD) conductivity (n = 3, median age 6.6 years, range 1.9-40.5) was 34.3 (6.5 mmol/l).
CONCLUSION
In sweat of 11 patients with G6PD deficiency we did not find any abnormality. The reason for alleged false-positive sweat test in patients with G6PD deficiency is not known and we were unable to identify any original reference. It appears that tables of putative false-positive sweat tests in several disease states have been directly "copied and pasted" from one paper or textbook to another without verifying the original literature, a phenomenon one can call "chain citation".
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1136/adc.2007.132688
- PMID 18456694
- Persistent URL
- https://sonar.ch/global/documents/172402
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