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Transcriptional Control of Dendritic Cell Development.

  • Murphy TL Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, Missouri 63110; email: tmurphy@wustl.edu.
  • Grajales-Reyes GE Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, Missouri 63110; email: tmurphy@wustl.edu.
  • Wu X Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, Missouri 63110; email: tmurphy@wustl.edu.
  • Tussiwand R Department of Biomedicine, University of Basel, 4058 Basel, Switzerland.
  • Briseño CG Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, Missouri 63110; email: tmurphy@wustl.edu.
  • Iwata A Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, Missouri 63110; email: tmurphy@wustl.edu.
  • Kretzer NM Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, Missouri 63110; email: tmurphy@wustl.edu.
  • Durai V Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, Missouri 63110; email: tmurphy@wustl.edu.
  • Murphy KM Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, Missouri 63110; email: tmurphy@wustl.edu.
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  • 2016-01-07
Published in:
  • Annual review of immunology. - 2016
common dendritic progenitor
dendritic cell
lineage commitment
transcription factors
Animals
Bone Marrow Cells
Cell Differentiation
Cell Lineage
Dendritic Cells
Gene Expression Profiling
Gene Expression Regulation
Gene Regulatory Networks
Humans
Immunity, Cellular
Mice
Transcriptional Activation
English The dendritic cells (DCs) of the immune system function in innate and adaptive responses by directing activity of various effector cells rather than serving as effectors themselves. DCs and closely related myeloid lineages share expression of many surface receptors, presenting a challenge in distinguishing their unique in vivo functions. Recent work has taken advantage of unique transcriptional programs to identify and manipulate murine DCs in vivo. This work has assigned several nonredundant in vivo functions to distinct DC lineages, consisting of plasmacytoid DCs and several subsets of classical DCs that promote different immune effector modules in response to pathogens. In parallel, a correspondence between human and murine DC subsets has emerged, underlying structural similarities for the DC lineages between these species. Recent work has begun to unravel the transcriptional circuitry that controls the development and diversification of DCs from common progenitors in the bone marrow.
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  • English
Open access status
green
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https://sonar.ch/global/documents/173678
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