Morphogen gradient formation.
- Wartlick O Department of Biochemistry, University of Geneva, 1211 Geneva, Switzerland.
- Kicheva A
- González-Gaitán M
- 2010-01-13
Published in:
- Cold Spring Harbor perspectives in biology. - 2009
Animals
Body Patterning
Cell Biology
Cell Differentiation
Cell Lineage
Developmental Biology
Diffusion
Green Fluorescent Proteins
Humans
Kinetics
Models, Biological
Models, Statistical
Morphogenesis
Mutation
English
How morphogen gradients are formed in target tissues is a key question for understanding the mechanisms of morphological patterning. Here, we review different mechanisms of morphogen gradient formation from theoretical and experimental points of view. First, a simple, comprehensive overview of the underlying biophysical principles of several mechanisms of gradient formation is provided. We then discuss the advantages and limitations of different experimental approaches to gradient formation analysis.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1101/cshperspect.a001255
- PMID 20066104
- Persistent URL
- https://sonar.ch/global/documents/174520
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