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A novel thermoresponsive hydrogel based on chitosan.
Journal article

A novel thermoresponsive hydrogel based on chitosan.

  • Schuetz YB Department of Pharmaceutics and Biopharmaceutics, School of Pharmaceutical Sciences, University of Geneva, 30 Quai Ernest-Ansermet, Geneva, Switzerland.
  • Gurny R
  • Jordan O
  • 2007-09-22
Published in:
  • European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. - 2008
Biocompatible Materials
Chitosan
Drug Carriers
Drug Stability
Drug Storage
Excipients
Freeze Drying
Freezing
Gels
Hydrogels
Injections
Molecular Weight
Steam
Sterilization
Temperature
Tissue Engineering
English Injectable thermosetting chitosan hydrogels are attractive systems for drug delivery and tissue engineering that combine biodegradability, biocompatibility and the ability to form in situ gel-like implants. Thermally-induced gelation relies advantageously on biopolymer secondary interactions, avoiding potentially toxic polymerization reactions that may occur with in situ polymerizing formulations. In view of a biomedical use, such formulations have to be sterilizable and storable on extended periods without losing their thermosetting properties. These two key features have been studied in the present paper. Chitosans from two different sources were added with several phosphate-free polyols or polyoses as gelling agents. Despite a reduction in chitosan molecular weight following autoclaving, the hydrogels prepared with autoclaved chitosan showed the desired thermosetting properties. Hence, chitosan steam sterilization combined with aseptic preparation of the hydrogel allows a sterile formulation to be obtained. Whereas thermosetting hydrogels were shown to be unstable when refrigerated, freezing was shown to be conceivable as a storage method. When trehalose or mannitol was used as stabilizing agent, the formulation reconstituted from a lyophilizate displayed thermosetting properties and was still injectable, paving the way to the development of a clinically utilizable, novel chitosan thermosetting hydrogel.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/174533
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