Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphoma.

• Crescenzo R Department of Molecular Biotechnology and Health Science and Center for Experimental Research and Medical Studies, University of Torino, 10126 Torino, Italy; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10021, USA.
• Abate F Department of Molecular Biotechnology and Health Science and Center for Experimental Research and Medical Studies, University of Torino, 10126 Torino, Italy; Department of Control and Computer Engineering, Politecnico di Torino, 10129 Torino, Italy; Department of Biomedical Informatics and Department of Systems Biology, Center for Computational Biology and Bioinformatics, Columbia University, New York, NY 10027, USA.
• Lasorsa E Department of Molecular Biotechnology and Health Science and Center for Experimental Research and Medical Studies, University of Torino, 10126 Torino, Italy.
• Tabbo' F Department of Molecular Biotechnology and Health Science and Center for Experimental Research and Medical Studies, University of Torino, 10126 Torino, Italy; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10021, USA.
• Gaudiano M Department of Molecular Biotechnology and Health Science and Center for Experimental Research and Medical Studies, University of Torino, 10126 Torino, Italy; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10021, USA.
• Chiesa N Department of Molecular Biotechnology and Health Science and Center for Experimental Research and Medical Studies, University of Torino, 10126 Torino, Italy.
• Di Giacomo F Department of Molecular Biotechnology and Health Science and Center for Experimental Research and Medical Studies, University of Torino, 10126 Torino, Italy.
• Spaccarotella E Department of Molecular Biotechnology and Health Science and Center for Experimental Research and Medical Studies, University of Torino, 10126 Torino, Italy.
• Barbarossa L Department of Molecular Biotechnology and Health Science and Center for Experimental Research and Medical Studies, University of Torino, 10126 Torino, Italy.
• Ercole E Department of Molecular Biotechnology and Health Science and Center for Experimental Research and Medical Studies, University of Torino, 10126 Torino, Italy.
• Todaro M Department of Molecular Biotechnology and Health Science and Center for Experimental Research and Medical Studies, University of Torino, 10126 Torino, Italy; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10021, USA.
• Boi M Department of Molecular Biotechnology and Health Science and Center for Experimental Research and Medical Studies, University of Torino, 10126 Torino, Italy; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10021, USA.
• Acquaviva A Department of Control and Computer Engineering, Politecnico di Torino, 10129 Torino, Italy.
• Ficarra E Department of Control and Computer Engineering, Politecnico di Torino, 10129 Torino, Italy.
• Novero D Department of Pathology, A.O. Città della Salute e della Scienza (Molinette), 10126 Torino, Italy.
• Rinaldi A Lymphoma and Genomics Research Program, Institute of Oncology Research, 6500 Bellinzona, Switzerland.
• Tousseyn T Translational Cell and Tissue Research Lab, KU Leuven, 3000 Leuven, Belgium.
• Rosenwald A Institute of Pathology, University of Würzburg and Comprehensive Cancer Center Mainfranken, 97080 Würzburg, Germany.
• Kenner L Ludwing Boltzmann Institute for Cancer Research, 1090 Vienna, Austria.
• Cerroni L Research Unit Dermatopathology of the Medical University of Graz, 8036 Graz, Austria.
• Tzankov A Institute of Pathology, University Hospital Basel, 4031 Basel, Switzerland.
• Ponzoni M Pathology & Lymphoid Malignancies Units, San Raffaele Scientific Institute, 20132 Milan, Italy.
• Paulli M Department of Human Pathology, University of Pavia and Scientific Institute Fondazione Policlinico San Matteo, 27100 Pavia, Italy.
• Weisenburger D Department of Pathology, City of Hope Medical Center, Duarte, CA 91010, USA.
• Chan WC Department of Pathology, City of Hope Medical Center, Duarte, CA 91010, USA.
• Iqbal J Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
• Piris MA Cancer Genomics, Instituto de Formación e Investigación Marqués de Valdecilla and Department of Pathology, Hospital Universitario Marqués de Valdecilla, 39008 Santander, Spain.
• Zamo' A Department of Pathology and Diagnostics, University of Verona, 37134 Verona, Italy.
• Ciardullo C Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, 28100 Novara, Italy.
• Rossi D Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, 28100 Novara, Italy.
• Gaidano G Division of Hematology, Department of Translational Medicine, Amedeo Avogadro University of Eastern Piedmont, 28100 Novara, Italy.
• Pileri S European Institute of Oncology, 20141 Milano, Italy; Bologna University School of Medicine, 40126 Bologna, Italy.
• Tiacci E Institute of Hematology-Centro di Ricerche Onco-Ematologiche (CREO), Ospedale S. Maria della Misericordia, University of Perugia, 06100 Perugia, Italy.
• Falini B Institute of Hematology-Centro di Ricerche Onco-Ematologiche (CREO), Ospedale S. Maria della Misericordia, University of Perugia, 06100 Perugia, Italy.
• Shultz LD The Jackson Laboratory, Bar Harbor, ME 04609, USA.
• Mevellec L Janssen Research & Development, a Division of Janssen-Cilag, Campus de Maigremont, CS10615, 27106 Val-de-Reuil Cedex, France.
• Vialard JE Janssen Research & Development, a Division of Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium.
• Piva R Department of Molecular Biotechnology and Health Science and Center for Experimental Research and Medical Studies, University of Torino, 10126 Torino, Italy; Department of Pathology and NYU Cancer Center, New York University School of Medicine, New York, NY 10016, USA.
• Bertoni F Lymphoma and Genomics Research Program, Institute of Oncology Research, 6500 Bellinzona, Switzerland; Oncology Institute of Southern Switzerland, 6500 Bellinzona, Switzerland.
• Rabadan R Department of Biomedical Informatics and Department of Systems Biology, Center for Computational Biology and Bioinformatics, Columbia University, New York, NY 10027, USA. Electronic address: rr2579@cumc.columbia.edu.
• Inghirami G Department of Molecular Biotechnology and Health Science and Center for Experimental Research and Medical Studies, University of Torino, 10126 Torino, Italy; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10021, USA; Department of Pathology and NYU Cancer Center, New York University School of Medicine, New York, NY 10016, USA. Electronic address: ggi9001@med.cornell.edu.

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Activating Transcription Factor 3

Animals

Cell Line, Tumor

Gene Expression Regulation, Neoplastic

HEK293 Cells

Humans

Janus Kinase 1

Lymphoma, Large-Cell, Anaplastic

Mice

Mutant Chimeric Proteins

NF-kappa B

Phosphorylation

Proto-Oncogene Proteins

Receptor Protein-Tyrosine Kinases

STAT3 Transcription Factor

Signal Transduction

TYK2 Kinase