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Rational design of dinitroxide biradicals for efficient cross-effect dynamic nuclear polarization.
Journal article

Rational design of dinitroxide biradicals for efficient cross-effect dynamic nuclear polarization.

  • Kubicki DJ Institut des Sciences et Ingénierie Chimiques , Ecole Polytechnique Fédérale de Lausanne (EPFL) , CH-1015 Lausanne , Switzerland . Email: lyndon.emsley@ens-lyon.fr.
  • Casano G Aix-Marseille Université , CNRS , ICR UMR 7273 , 13397 Marseille , France . Email: paul.tordo@univ-amu.fr ; Email: olivier.ouari@univ-amu.fr.
  • Schwarzwälder M ETH Zurich , Department of Chemistry, Laboratory of Inorganic Chemistry , 8093 Zurich , Switzerland.
  • Abel S Aix-Marseille Université , CNRS , ICR UMR 7273 , 13397 Marseille , France . Email: paul.tordo@univ-amu.fr ; Email: olivier.ouari@univ-amu.fr.
  • Sauvée C Aix-Marseille Université , CNRS , ICR UMR 7273 , 13397 Marseille , France . Email: paul.tordo@univ-amu.fr ; Email: olivier.ouari@univ-amu.fr.
  • Ganesan K Aix-Marseille Université , CNRS , ICR UMR 7273 , 13397 Marseille , France . Email: paul.tordo@univ-amu.fr ; Email: olivier.ouari@univ-amu.fr.
  • Yulikov M ETH Zurich , Department of Chemistry, Laboratory of Inorganic Chemistry , 8093 Zurich , Switzerland.
  • Rossini AJ Institut des Sciences et Ingénierie Chimiques , Ecole Polytechnique Fédérale de Lausanne (EPFL) , CH-1015 Lausanne , Switzerland . Email: lyndon.emsley@ens-lyon.fr.
  • Jeschke G ETH Zurich , Department of Chemistry, Laboratory of Inorganic Chemistry , 8093 Zurich , Switzerland.
  • Copéret C ETH Zurich , Department of Chemistry, Laboratory of Inorganic Chemistry , 8093 Zurich , Switzerland.
  • Lesage A Université de Lyon , Institut de Sciences Analytiques (CNRS / ENS de Lyon / UCB-Lyon 1) , Centre de RMN à Très Hauts Champs , 69100 Villeurbanne , France.
  • Tordo P Aix-Marseille Université , CNRS , ICR UMR 7273 , 13397 Marseille , France . Email: paul.tordo@univ-amu.fr ; Email: olivier.ouari@univ-amu.fr.
  • Ouari O Aix-Marseille Université , CNRS , ICR UMR 7273 , 13397 Marseille , France . Email: paul.tordo@univ-amu.fr ; Email: olivier.ouari@univ-amu.fr.
  • Emsley L Institut des Sciences et Ingénierie Chimiques , Ecole Polytechnique Fédérale de Lausanne (EPFL) , CH-1015 Lausanne , Switzerland . Email: lyndon.emsley@ens-lyon.fr.
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  • 2018-06-14
Published in:
  • Chemical science. - 2016
General Chemistry
English A series of 37 dinitroxide biradicals have been prepared and their performance studied as polarizing agents in cross-effect DNP NMR experiments at 9.4 T and 100 K in 1,1,2,2-tetrachloroethane (TCE). We observe that in this regime the DNP performance is strongly correlated with the substituents on the polarizing agents, and electron and nuclear spin relaxation times, with longer relaxation times leading to better enhancements. We also observe that deuteration of the radicals generally leads to better DNP enhancement but with longer build-up time. One of the new radicals introduced here provides the best performance obtained so far under these conditions.
Language
  • English
Open access status
gold
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Persistent URL
https://sonar.ch/global/documents/176336
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