Back
mTORC1 signaling in Agrp neurons mediates circadian expression of Agrp and NPY but is dispensable for regulation of feeding behavior.
Journal article

mTORC1 signaling in Agrp neurons mediates circadian expression of Agrp and NPY but is dispensable for regulation of feeding behavior.

  • Albert V Biozentrum, University of Basel, Klingelbergstrasse 50/70, 4056 Basel, Switzerland.
  • Cornu M Biozentrum, University of Basel, Klingelbergstrasse 50/70, 4056 Basel, Switzerland.
  • Hall MN Biozentrum, University of Basel, Klingelbergstrasse 50/70, 4056 Basel, Switzerland. Electronic address: m.hall@unibas.ch.
  • 2015-07-11
Published in:
  • Biochemical and biophysical research communications. - 2015
Agrp
Hypothalamus
Metabolism
NPY
Raptor
mTORC1
Adaptor Proteins, Signal Transducing
Agouti-Related Protein
Animals
Circadian Rhythm
Feeding Behavior
Mechanistic Target of Rapamycin Complex 1
Mice
Mice, Knockout
Multiprotein Complexes
Neurons
Neuropeptide Y
Oxidative Stress
Regulatory-Associated Protein of mTOR
Signal Transduction
TOR Serine-Threonine Kinases
English Orexigenic agouti-related protein/neuropeptide Y (Agrp/NPY) neurons and an orexigenic pro-opiomelanocortin (POMC) neurons of the hypothalamus regulate feeding behavior and energy homeostasis. An understanding of the molecular signaling pathways that regulate Agrp/NPY and POMC function could lead to novel treatments for metabolic disorders. Target of Rapamycin Complex 1 (TORC1) is a nutrient-activated protein kinase and central controller of growth and metabolism. We therefore investigated the role of mammalian TORC1 (mTORC1) in Agrp neurons. We generated and characterized Agrp neuron-specific raptor knockout (Agrp-raptor KO) mice. Agrp-raptor KO mice displayed reduced, non-circadian expression of Agrp and NPY but normal feeding behavior and energy homeostasis on both normal and high fat diet. Thus, mTORC1 in Agrp neurons controls circadian expression of orexigenic neuropeptides but is dispensable for the regulation of feeding behavior and energy metabolism.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/17676
Statistics
Document views: 23 File downloads: