Back
Translating Hedgehog in Cancer: Controlling Protein Synthesis.
Journal article

Translating Hedgehog in Cancer: Controlling Protein Synthesis.

  • D'Amico D Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
  • Canettieri G Department of Molecular Medicine, Sapienza University, 00161 Rome, Italy. Electronic address: gianluca.canettieri@uniroma1.it.
  • 2016-09-04
Published in:
  • Trends in molecular medicine. - 2016
Cancer
Cap
Hedgehog
IRES
translation
Animals
Antineoplastic Agents
Drug Discovery
Hedgehog Proteins
Humans
Internal Ribosome Entry Sites
Molecular Targeted Therapy
Neoplasms
Protein Biosynthesis
RNA, Messenger
Signal Transduction
English Developmental Hedgehog (Hh) signaling is found deregulated in a broad spectrum of human malignancies and, thus, is an attractive target for cancer therapy. Currently available Hh inhibitors have shown the rapid occurrence of drug resistance, due to altered signaling in collateral pathways. Emerging observations suggest that Hh signaling regulates protein translation in pathways that depend both on Cap- and IRES-mediated translation. In addition, translational regulators have been shown to modulate Hh function. In this opinion, we describe this novel Hh/translation crosstalk and argue that it plays a relevant role in Hh-mediated tumorigenesis and drug resistance. As such, we suggest that drugs targeting translation might be introduced in novel protocols aimed at treating malignancies driven by aberrant Hh signaling.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/177059
Statistics
Document views: 24 File downloads: