Automated synthesis of sialylated oligosaccharides
- 2012-9-21
Published in:
- Beilstein Journal of Organic Chemistry. - Beilstein Institut. - 2012, vol. 8, p. 1601-1609
English
Sialic acid-containing glycans play a major role in cell-surface interactions with external partners such as cells and viruses. Straightforward access to sialosides is required in order to study their biological functions on a molecular level. Here, automated oligosaccharide synthesis was used to facilitate the preparation of this class of biomolecules. Our strategy relies on novel sialyl α-(2→3) and α-(2→6) galactosyl imidates, which, used in combination with the automated platform, provided rapid access to a small library of conjugation-ready sialosides of biological relevance.
- Language
-
- English
- Open access status
- gold
- Identifiers
-
- DOI 10.3762/bjoc.8.183
- ISSN 1860-5397
- Persistent URL
- https://sonar.ch/global/documents/177602
Export to…
Statistics
Document views: 34
File downloads:
- Full-text: 0