Localization of Hidden Insulinomas with ⁶⁸Ga-DOTA-Exendin-4 PET/CT: A Pilot Study.
- Antwi K Clinic of Radiology and Nuclear Medicine, University of Basel Hospital, Basel, Switzerland.
- Fani M Clinic of Radiology and Nuclear Medicine, University of Basel Hospital, Basel, Switzerland.
- Nicolas G Clinic of Radiology and Nuclear Medicine, University of Basel Hospital, Basel, Switzerland.
- Rottenburger C Clinic of Radiology and Nuclear Medicine, University of Basel Hospital, Basel, Switzerland.
- Heye T Clinic of Radiology and Nuclear Medicine, University of Basel Hospital, Basel, Switzerland.
- Reubi JC Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Bern, Bern, Switzerland.
- Gloor B Department of Visceral Surgery, University Hospital of Bern, Bern, Switzerland; and.
- Christ E Division of Endocrinology, Diabetology, and Clinical Nutrition, University Hospital of Bern, Bern Switzerland.
- Wild D Clinic of Radiology and Nuclear Medicine, University of Basel Hospital, Basel, Switzerland damian.wild@usb.ch.
- 2015-05-23
Published in:
- Journal of nuclear medicine : official publication, Society of Nuclear Medicine. - 2015
68Ga
exendin-4
glucagon-like peptide-1 receptor targeting
insulinoma
Adult
Cross-Over Studies
Diagnostic Imaging
Exenatide
Female
Gallium Radioisotopes
Glucose
Heterocyclic Compounds, 1-Ring
Humans
Immunohistochemistry
Insulinoma
Male
Middle Aged
Multimodal Imaging
Peptides
Pilot Projects
Positron-Emission Tomography
Tomography, Emission-Computed, Single-Photon
Tomography, X-Ray Computed
Venoms
Whole Body Imaging
English
UNLABELLED
(111)In-DOTA-exendin-4 SPECT/CT has been shown to be highly efficient in the detection of insulinomas. We aimed at determining whether novel PET/CT imaging with [Nle(14),Lys(40)(Ahx-DOTA-(68)Ga)NH2]exendin-4 ((68)Ga-DOTA-exendin-4) is feasible and sensitive in detecting benign insulinomas.
METHODS
(68)Ga-DOTA-exendin-4 PET/CT and (111)In-DOTA-exendin-4 SPECT/CT were performed in a randomized cross-over order on 5 patients with endogenous hyperinsulinemic hypoglycemia. The gold standard for comparison was the histologic diagnosis after surgery.
RESULTS
In 4 patients histologic diagnosis confirmed a benign insulinoma, whereas one patient refused surgery despite a positive (68)Ga-DOTA-exendin-4 PET/CT scan. In 4 of 5 patients, previously performed conventional imaging (CT or MR imaging) was not able to localize the insulinoma. (68)Ga-DOTA-exendin-4 PET/CT correctly identified the insulinoma in 4 of 4 patients, whereas (111)In-DOTA-exendin-4 SPECT/CT correctly identified the insulinoma in only 2 of 4 patients.
CONCLUSION
These preliminary data suggest that the use of (68)Ga-DOTA-exendin-4 PET/CT in detecting hidden insulinomas is feasible.
(111)In-DOTA-exendin-4 SPECT/CT has been shown to be highly efficient in the detection of insulinomas. We aimed at determining whether novel PET/CT imaging with [Nle(14),Lys(40)(Ahx-DOTA-(68)Ga)NH2]exendin-4 ((68)Ga-DOTA-exendin-4) is feasible and sensitive in detecting benign insulinomas.
METHODS
(68)Ga-DOTA-exendin-4 PET/CT and (111)In-DOTA-exendin-4 SPECT/CT were performed in a randomized cross-over order on 5 patients with endogenous hyperinsulinemic hypoglycemia. The gold standard for comparison was the histologic diagnosis after surgery.
RESULTS
In 4 patients histologic diagnosis confirmed a benign insulinoma, whereas one patient refused surgery despite a positive (68)Ga-DOTA-exendin-4 PET/CT scan. In 4 of 5 patients, previously performed conventional imaging (CT or MR imaging) was not able to localize the insulinoma. (68)Ga-DOTA-exendin-4 PET/CT correctly identified the insulinoma in 4 of 4 patients, whereas (111)In-DOTA-exendin-4 SPECT/CT correctly identified the insulinoma in only 2 of 4 patients.
CONCLUSION
These preliminary data suggest that the use of (68)Ga-DOTA-exendin-4 PET/CT in detecting hidden insulinomas is feasible.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.2967/jnumed.115.157768
- PMID 25999434
- Persistent URL
- https://sonar.ch/global/documents/177909
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