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Regulating the balance between necroptosis, apoptosis and inflammation by inhibitors of apoptosis proteins.
Journal article

Regulating the balance between necroptosis, apoptosis and inflammation by inhibitors of apoptosis proteins.

  • Vasilikos L Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
  • Spilgies LM Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
  • Knop J Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
  • Wong WW Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
  • 2016-12-02
Published in:
  • Immunology and cell biology. - 2017
Animals
Apoptosis
Cell Survival
Humans
Inflammation
Inhibitor of Apoptosis Proteins
Models, Genetic
Necrosis
English Understanding how inhibitor of apoptosis proteins (IAPs) regulate apoptosis and necroptosis has been fast-forwarded by the use of Smac mimetics (SMs) to deplete or inhibit the IAPs, specifically cIAP1, cIAP2 and XIAP. The loss or inhibition of cIAP1, cIAP2 and XIAP causes the majority of cells to be sensitized to death receptor induced cell death, such as with tumour necrosis factor (TNF). Mouse genetics shows that there is some functional redundancy and the use of SMs has allowed us to understand how changing the composition of proteins recruited to TNF receptor 1 on TNF ligation can alter protein complex formation and activation of apoptosis or necroptosis, particularly when caspases are inhibited. Determining when or how caspase inhibition occurs physiologically combined with the loss of IAPs will be the next challenge in understanding the ability of IAPs to prevent cell death and/or limit inflammation.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/178627
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