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Global, Regional, and National Burden of Calcific Aortic Valve and Degenerative Mitral Valve Diseases, 1990-2017.
Journal article

Global, Regional, and National Burden of Calcific Aortic Valve and Degenerative Mitral Valve Diseases, 1990-2017.

  • Yadgir S Institute for Health Metrics and Evaluation (S.Y., C.O.J., C.M.B., S.I.H., A.H.M., M.R.N., G.A.R.), University of Washington, Seattle.
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  • Aboyans V Department of Cardiology, Dupuytren University Hospital, Limoges, France (V. Aboyans).
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  • Alashi A Department of Cardiovascular Medicine (A.A., M.M.G.), Cleveland Clinic, OH.
  • Alipour V Health Management and Economics Research Center (V. Alipour, J.A., S.A., A. Rezapour), Iran University of Medical Sciences, Tehran.
  • Arabloo J Health Management and Economics Research Center (V. Alipour, J.A., S.A., A. Rezapour), Iran University of Medical Sciences, Tehran.
  • Azari S Health Management and Economics Research Center (V. Alipour, J.A., S.A., A. Rezapour), Iran University of Medical Sciences, Tehran.
  • Barthelemy CM Institute for Health Metrics and Evaluation (S.Y., C.O.J., C.M.B., S.I.H., A.H.M., M.R.N., G.A.R.), University of Washington, Seattle.
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  • Berman AE Department of Medicine, Medical College of Georgia at Augusta University (A.E.B.).
  • Bijani A Social Determinants of Health Research Center, Babol University of Medical Sciences, Mazandaran, Iran (A.B.).
  • Carrero JJ Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (J.J.C.).
  • Carvalho F Applied Molecular Biosciences Unit (F.C.), University of Porto, Portugal.
  • Daryani A Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran (A.D.).
  • Durães AR Endocrinology and Metabolism Research Center (M.A., A.E.), Tehran University of Medical Sciences, Iran.
  • Esteghamati A Division of Cardiovascular Medicine, University of Louisville, KY (T.A.F., A.R.K.).
  • Farid TA Non-communicable Diseases Research Center (F.F.), Tehran University of Medical Sciences, Iran.
  • Farzadfar F REQUIMTE/LAQV (E.F.), University of Porto, Portugal.
  • Fernandes E Psychiatry Department, Kaiser Permanente, Fontana, CA (I.F.).
  • Filip I Department of Cardiovascular Medicine (A.A., M.M.G.), Cleveland Clinic, OH.
  • Gad MM School of Health and Environmental Studies, Hamdan Bin Mohammed Smart University, Dubai, United Arab Emirates (S.H.).
  • Hamidi S Institute for Health Metrics and Evaluation (S.Y., C.O.J., C.M.B., S.I.H., A.H.M., M.R.N., G.A.R.), University of Washington, Seattle.
  • Hay SI Department of Community Medicine, University of Ibadan, Nigeria (O.S.I.).
  • Ilesanmi OS Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran (S.S.N.I.).
  • Naghibi Irvani SS Institute of Family Medicine and Public Health, University of Tartu, Tartumaa, Estonia (M.J.).
  • Jürisson M Hematology-Oncology and Stem Cell Transplantation Research Center (A. Kasaeian), Tehran University of Medical Sciences, Iran.
  • Kasaeian A Non-communicable Diseases Research Unit, Medical Research Council South Africa, Cape Town (A.P.K.).
  • Kengne AP Division of Cardiovascular Medicine, University of Louisville, KY (T.A.F., A.R.K.).
  • Khan AR Department of Health Management and Health Economics, Kristiania University College, Oslo, Norway (A. Kisa).
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  • Kisa S Department of Medicine, Brown University, Providence, RI (D.K.).
  • Kolte D Ophthalmology Department (N.M.), Iran University of Medical Sciences, Tehran.
  • Manafi N Department of Surgery, University of Virginia, Charlottesville (A.M.).
  • Manafi A Department of Medicine, University of Cape Town, South Africa (A.P.K., G.A.M., K.S.).
  • Mensah GA Faculty of General Medicine, Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan (E.M.M.).
  • Mirrakhimov EM Internal Medicine Department, King Saud University, Riyadh, Saudi Arabia (Y.M.).
  • Mohammad Y Institute for Health Metrics and Evaluation (S.Y., C.O.J., C.M.B., S.I.H., A.H.M., M.R.N., G.A.R.), University of Washington, Seattle.
  • Mokdad AH Anatomy and Embryology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania (R.I.N.).
  • Negoi RI Institute for Global Health Innovations, Duy Tan University, Hanoi, Vietnam (H.L.T.N.).
  • Thi Nguyen HL Center of Excellence in Behavioral Health, Nguyen Tat Thanh University, Ho Chi Minh City, Vietnam (T.H.N.).
  • Nguyen TH Institute for Health Metrics and Evaluation (S.Y., C.O.J., C.M.B., S.I.H., A.H.M., M.R.N., G.A.R.), University of Washington, Seattle.
  • Nixon MR Division of Cardiology (C.M.O., G.A.R.), University of Washington, Seattle.
  • Otto CM Department of Medicine, Maimonides Medical Center, Brooklyn, NY (S.P.).
  • Patel S Department of Cardiology, University of Bern, Switzerland (T.P.).
  • Pilgrim T College of Graduate Health Sciences, A.T. Still University, Mesa, AZ (A. Radfar).
  • Radfar A WHO Collaborating Centre for Public Health Education and Training (D.L.R.), Imperial College London, United Kingdom.
  • Rawaf DL Department of Primary Care and Public Health (S.R.), Imperial College London, United Kingdom.
  • Rawaf S Cardiovascular Medicine, West Virginia University, Morgantown (W.F.R.).
  • Rawasia WF Health Management and Economics Research Center (V. Alipour, J.A., S.A., A. Rezapour), Iran University of Medical Sciences, Tehran.
  • Rezapour A Department of Clinical Research, Federal University of Uberl ândia, Brazil (L.R.).
  • Roever L Faculty of Medicine, Ain Shams University, Cairo, Egypt (A.M.S.).
  • Saad AM Department of Cardiology (S. Saadatagah), Tehran University of Medical Sciences, Iran.
  • Saadatagah S Emergency Department, Manian Medical Centre, ERODE, Tamil Nadu, India (S. Senthilkumaran).
  • Senthilkumaran S Department of Medicine, University of Cape Town, South Africa (A.P.K., G.A.M., K.S.).
  • Sliwa K Department of Public Health, Adigrat University, Tigray, Ethiopia (B.E.T.).
  • Tesfay BE Department of Health Economics, Hanoi Medical University, Vietnam (B.X.T.).
  • Tran BX Gomal Center of Biochemistry and Biotechnology, Gomal University, Faisalabad, Pakistan (I.U.).
  • Ullah I Heart and Vascular Center, Harvard University, Boston, MA (M.V.).
  • Vaduganathan M UKK Institute, Tampere, Finland (T.J.V.).
  • Vasankari TJ School of Population Health & Environmental Sciences, King's College London, United Kingdom (C.D.A.W.).
  • Wolfe CDA Department of Psychopharmacology, National Center of Neurology and Psychiatry, Tokyo, Japan (N.Y.).
  • Yonemoto N Institute for Health Metrics and Evaluation (S.Y., C.O.J., C.M.B., S.I.H., A.H.M., M.R.N., G.A.R.), University of Washington, Seattle.
  • Roth GA
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  • 2020-04-01
Published in:
  • Circulation. - 2020
English BACKGROUND
Nonrheumatic valvular diseases are common; however, no studies have estimated their global or national burden. As part of the Global Burden of Disease Study 2017, mortality, prevalence, and disability-adjusted life-years (DALYs) for calcific aortic valve disease (CAVD), degenerative mitral valve disease, and other nonrheumatic valvular diseases were estimated for 195 countries and territories from 1990 to 2017.


METHODS
Vital registration data, epidemiologic survey data, and administrative hospital data were used to estimate disease burden using the Global Burden of Disease Study modeling framework, which ensures comparability across locations. Geospatial statistical methods were used to estimate disease for all countries, because data on nonrheumatic valvular diseases are extremely limited for some regions of the world, such as Sub-Saharan Africa and South Asia. Results accounted for estimated level of disease severity as well as the estimated availability of valve repair or replacement procedures. DALYs and other measures of health-related burden were generated for both sexes and each 5-year age group, location, and year from 1990 to 2017.


RESULTS
Globally, CAVD and degenerative mitral valve disease caused 102 700 (95% uncertainty interval [UI], 82 700-107 900) and 35 700 (95% UI, 30 500-42 500) deaths, and 12.6 million (95% UI, 11.4 million-13.8 million) and 18.1 million (95% UI, 17.6 million-18.6 million) prevalent cases existed in 2017, respectively. A total of 2.5 million (95% UI, 2.3 million-2.8 million) DALYs were estimated as caused by nonrheumatic valvular diseases globally, representing 0.10% (95% UI, 0.09%-0.11%) of total lost health from all diseases in 2017. The number of DALYs increased for CAVD and degenerative mitral valve disease between 1990 and 2017 by 101% (95% UI, 79%-117%) and 35% (95% UI, 23%-47%), respectively. There is significant geographic variation in the prevalence, mortality rate, and overall burden of these diseases, with highest age-standardized DALY rates of CAVD estimated for high-income countries.


CONCLUSIONS
These global and national estimates demonstrate that CAVD and degenerative mitral valve disease are important causes of disease burden among older adults. Efforts to clarify modifiable risk factors and improve access to valve interventions are necessary if progress is to be made toward reducing, and eventually eliminating, the burden of these highly treatable diseases.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/178775
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