Journal article
ProFit revisited.
- Fuchs A Department of Information Technology and Electrical Engineering, Institute for Biomedical Engineering, ETH & University Zurich, Switzerland.
- Boesiger P
- Schulte RF
- Henning A
- 2013-03-12
Published in:
- Magnetic resonance in medicine. - 2014
Brain Chemistry
Humans
Magnetic Resonance Spectroscopy
Models, Theoretical
Software
Software Validation
English
PURPOSE
An enhanced version of the ProFit fitting tool was developed and validated to improve the quantification of two-dimensional JRPESS spectroscopic data.
METHODS
The proposed enhancements were achieved by flexible organization of prior knowledge, configurations for different situations, the inclusion of measured macromolecular baseline contribution, additional baseline splines and a model-free lineshape based on self-deconvolution. The new software was tested and tuned on simulated data and subsequently applied to in vivo intrasubject and intersubject data.
RESULTS
Fit results of simulated and acquired spectra show good overall quality suggesting the potential reliable detection of up to 18 metabolites on a 3T system yielding Cramer-Lower-Bounds below 20%.
CONCLUSION
The proposed enhanced version of ProFit together with two-dimensional J-resolved spectroscopy offers the opportunity to reliably detect a wide selection of important brain metabolites on 3T.
An enhanced version of the ProFit fitting tool was developed and validated to improve the quantification of two-dimensional JRPESS spectroscopic data.
METHODS
The proposed enhancements were achieved by flexible organization of prior knowledge, configurations for different situations, the inclusion of measured macromolecular baseline contribution, additional baseline splines and a model-free lineshape based on self-deconvolution. The new software was tested and tuned on simulated data and subsequently applied to in vivo intrasubject and intersubject data.
RESULTS
Fit results of simulated and acquired spectra show good overall quality suggesting the potential reliable detection of up to 18 metabolites on a 3T system yielding Cramer-Lower-Bounds below 20%.
CONCLUSION
The proposed enhanced version of ProFit together with two-dimensional J-resolved spectroscopy offers the opportunity to reliably detect a wide selection of important brain metabolites on 3T.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1002/mrm.24703
- PMID 23475809
- Persistent URL
- https://sonar.ch/global/documents/178934
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