Small supernumerary marker chromosomes: A legacy of trisomy rescue?

• Kurtas NE Department of Molecular Medicine, University of Pavia, Pavia, Italy.
• Xumerle L Department of Biotechnology, University of Verona, Verona, Italy.
• Leonardelli L Department of Biotechnology, University of Verona, Verona, Italy.
• Delledonne M Department of Biotechnology, University of Verona, Verona, Italy.
• Brusco A Department of Medical Sciences, University of Turin, Torino, Italy.
• Chrzanowska K Department of Medical Genetics, The Children's Memorial Health Institute, Warsaw, Poland.
• Schinzel A Institute of Medical Genetics, University of Zurich, Zurich, Switzerland.
• Larizza D Pediatrics and Adolescentology Unit, University of Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
• Guerneri S Laboratory of Medical Genetics, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
• Natacci F Laboratory of Medical Genetics, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
• Bonaglia MC Cytogenetics Laboratory, Scientific Institute, IRCCS Eugenio Medea, Bosisio Parini, Lecco, Italy.
• Reho P Biomedical Experimental and Clinical Sciences "Mario Serio", University of Florence, Firenze, Italy.
• Manolakos E Laboratory of Genetics, Access to genome P.C., Thessaloniki, Greece.
• Mattina T Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
• Soli F Department of Genetics, Santa Chiara Hospital, Trento, Italy.
• Provenzano A Biomedical Experimental and Clinical Sciences "Mario Serio", University of Florence, Firenze, Italy.
• Al-Rikabi AH Institute of Human Genetics, Jena University Hospital, Jena, Germany.
• Errichiello E Department of Molecular Medicine, University of Pavia, Pavia, Italy.
• Nazaryan-Petersen L Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
• Giglio S Biomedical Experimental and Clinical Sciences "Mario Serio", University of Florence, Firenze, Italy.
• Tommerup N Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
• Liehr T Institute of Human Genetics, Jena University Hospital, Jena, Germany.
• Zuffardi O Department of Molecular Medicine, University of Pavia, Pavia, Italy.

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chromothripsis

evolutionary trade-off

maternal meiotic nondisjunction

small supernumerary marker chromosome (sSMC)

whole genome paired-end sequencing (WGS)

Alleles

Chromosome Aberrations

Chromosomes

Chromothripsis

Comparative Genomic Hybridization

Female

Haplotypes

Humans

In Situ Hybridization, Fluorescence

Maternal Age

Maternal Inheritance

Mosaicism

Phenotype

Prenatal Diagnosis

Trisomy