Journal article

A network of trans-cortical capillaries as mainstay for blood circulation in long bones.

  • Grüneboom A Institute for Experimental Immunology and Imaging, University Hospital, University Duisburg-Essen, Essen, Germany.
  • Hawwari I Institute for Experimental Immunology and Imaging, University Hospital, University Duisburg-Essen, Essen, Germany.
  • Weidner D Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.
  • Culemann S Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.
  • Müller S Institute of Immunology, Universitätsklinikum Jena, Jena, Germany.
  • Henneberg S Institute for Experimental Immunology and Imaging, University Hospital, University Duisburg-Essen, Essen, Germany.
  • Brenzel A Institute for Experimental Immunology and Imaging, University Hospital, University Duisburg-Essen, Essen, Germany.
  • Merz S Institute for Experimental Immunology and Imaging, University Hospital, University Duisburg-Essen, Essen, Germany.
  • Bornemann L Institute for Experimental Immunology and Imaging, University Hospital, University Duisburg-Essen, Essen, Germany.
  • Zec K Institute for Experimental Immunology and Imaging, University Hospital, University Duisburg-Essen, Essen, Germany.
  • Wuelling M Department of Developmental Biology, Centre of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany.
  • Kling L Max Planck Institute for the Science of Light, Christiansen Research Group, Erlangen, Germany.
  • Hasenberg M Institute for Experimental Immunology and Imaging, University Hospital, University Duisburg-Essen, Essen, Germany.
  • Voortmann S Institute for Experimental Immunology and Imaging, University Hospital, University Duisburg-Essen, Essen, Germany.
  • Lang S Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.
  • Baum W Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.
  • Ohs A Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.
  • Kraff O Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen, Germany.
  • Quick HH Erwin L. Hahn Institute for Magnetic Resonance Imaging, University Duisburg-Essen, Essen, Germany.
  • Jäger M Department of Orthopaedics and Trauma Surgery, University Hospital, University Duisburg-Essen, Essen, Germany.
  • Landgraeber S Department of Orthopaedics and Trauma Surgery, University Hospital, University Duisburg-Essen, Essen, Germany.
  • Dudda M Department of Orthopaedics and Trauma Surgery, University Hospital, University Duisburg-Essen, Essen, Germany.
  • Danuser R Theodor Kocher Institute, University of Bern, Bern, Switzerland.
  • Stein JV Theodor Kocher Institute, University of Bern, Bern, Switzerland.
  • Rohde M Central Facility for Microscopy, Helmholtz Centre for Infection Research, Braunschweig, Germany.
  • Gelse K Department of Trauma Surgery, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), University Hospital of Erlangen, Erlangen, Germany.
  • Garbe AI Osteoimmunology, DFG-Center for Regenerative Therapies Dresden, Center for Molecular and Cellular Bioengineering (CMCB), Technische Universität Dresden, Cluster of Excellence, Dresden, Germany.
  • Adamczyk A Institute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
  • Westendorf AM Institute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
  • Hoffmann D Bioinformatics and Computational Biophysics, Faculty of Biology, University Duisburg-Essen, Essen, Germany.
  • Christiansen S Max Planck Institute for the Science of Light, Christiansen Research Group, Erlangen, Germany.
  • Engel DR Institute for Experimental Immunology and Imaging, University Hospital, University Duisburg-Essen, Essen, Germany.
  • Vortkamp A Department of Developmental Biology, Centre of Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany.
  • Krönke G Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.
  • Herrmann M Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.
  • Kamradt T Institute of Immunology, Universitätsklinikum Jena, Jena, Germany.
  • Schett G Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.
  • Hasenberg A Institute for Experimental Immunology and Imaging, University Hospital, University Duisburg-Essen, Essen, Germany.
  • Gunzer M Institute for Experimental Immunology and Imaging, University Hospital, University Duisburg-Essen, Essen, Germany.
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  • 2019-10-18
Published in:
  • Nature metabolism. - 2019
English Closed circulatory systems (CCS) underlie the function of vertebrate organs, but in long bones their structure is unclear, although they constitute the exit route for bone marrow (BM) leukocytes. To understand neutrophil emigration from BM, we studied the vascular system of murine long bones. Here we show that hundreds of capillaries originate in BM, cross murine cortical bone perpendicularly along the shaft and connect to the periosteal circulation. Structures similar to these trans-cortical-vessels (TCVs) also exist in human limb bones. TCVs express arterial or venous markers and transport neutrophils. Furthermore, over 80% arterial and 59% venous blood passes through TCVs. Genetic and drug-mediated modulation of osteoclast count and activity leads to substantial changes in TCV numbers. In a murine model of chronic arthritic bone inflammation, new TCVs develop within weeks. Our data indicate that TCVs are a central component of the CCS in long bones and may represent an important route for immune cell export from the BM.
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  • English
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https://sonar.ch/global/documents/179171
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