Clinical guide to fertility preservation in hematopoietic cell transplant recipients.
- Joshi S Nationwide Children's Hospital, Columbus, OH, USA.
- Savani BN Vanderbilt University Medical Center, Nashville, TN, USA.
- Chow EJ Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
- Gilleece MH Department of Haematology, St. James's University Hospital, Leeds, UK.
- Halter J Division of Hematology, University Hospital Basel, Basel, Switzerland.
- Jacobsohn DA Division of Blood and Marrow Transplantation, Children's National Medical Center, Washington, DC, USA.
- Pidala J Blood and Marrow Transplantation, Moffitt Cancer Center, Tampa, FL, USA.
- Quinn GP Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL, USA.
- Cahn JY Department of Hematology, University Hospital, Grenoble, France.
- Jakubowski AA Division of Hematologic Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
- Kamani NR Center for Cancer and Blood Disorders, Children's National Medical Center, Washington, DC, USA.
- Lazarus HM Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH, USA.
- Rizzo JD Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI, USA.
- Schouten HC University Hospital Maastricht, Maastricht, The Netherlands.
- Socie G Hopital Saint Louis, Paris, France.
- Stratton P Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.
- Sorror ML Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
- Warwick AB Department of Pediatrics, Uniformed Services University, Bethesda, MD, USA.
- Wingard JR Bone Marrow Transplant, Shands HealthCare, University of Florida, Gainesville, FL, USA.
- Loren AW Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
- Majhail NS Center for International Blood and Marrow Transplant Research, National Marrow Donor Program, Minneapolis, MN, USA.
- 2014-01-15
Published in:
- Bone marrow transplantation. - 2014
Female
Fertility Preservation
Hematopoietic Stem Cell Transplantation
Humans
Male
Pregnancy
Transplantation Conditioning
Transplantation, Homologous
English
With broadening indications, more options for hematopoietic cell transplantation (HCT) and improvement in survival, the number of long-term HCT survivors is expected to increase steadily. Infertility is a frequent problem that long-term HCT survivors and their partners face and it can negatively impact on the quality of life. The most optimal time to address fertility issues is before the onset of therapy for the underlying disease; however, fertility preservation should also be addressed before HCT in all children and patients of reproductive age, with referral to a reproductive specialist for patients interested in fertility preservation. In vitro fertilization (IVF) and embryo cryopreservation, oocyte cryopreservation and ovarian tissue banking are acceptable methods for fertility preservation in adult women/pubertal females. Sperm banking is the preferred method for adult men/pubertal males. Frequent barriers to fertility preservation in HCT recipients may include the perception of lack of time to preserve fertility given an urgency to move ahead with transplant, lack of patient-physician discussion because of several factors (for example, time constraints, lack of knowledge), inadequate access to reproductive specialists, and costs and lack of insurance coverage for fertility preservation. There is a need to raise awareness in the medical community about fertility preservation in HCT recipients.
- Language
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- English
- Open access status
- bronze
- Identifiers
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- DOI 10.1038/bmt.2013.211
- PMID 24419521
- Persistent URL
- https://sonar.ch/global/documents/18001
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