Journal article
Alpha rhythm and hypofrontality in schizophrenia.
- Knyazeva MG Department of Neurology, Centre Hospitalier Universitaire Vaudois and University of Lausanne and Department of Radiology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland. maria.knyazeva@chuv.ch
- Jalili M
- Meuli R
- Hasler M
- De Feo O
- Do KQ
- 2008-07-19
Published in:
- Acta psychiatrica Scandinavica. - 2008
Adolescent
Adult
Alpha Rhythm
Brain Mapping
Dominance, Cerebral
Female
Humans
Male
Middle Aged
Prefrontal Cortex
Psychiatric Status Rating Scales
Reproducibility of Results
Rest
Schizophrenia
Schizophrenic Psychology
Sensitivity and Specificity
Signal Processing, Computer-Assisted
Young Adult
English
OBJECTIVE
To reveal the EEG correlates of resting hypofrontality in schizophrenia (SZ).
METHOD
We analyzed the whole-head EEG topography in 14 patients compared to 14 matched controls by applying a new parameterization of the multichannel EEG. We used a combination of power measures tuned for regional surface mapping with power measures that allow evaluation of global effects.
RESULTS
The SZ-related EEG abnormalities include i) a global decrease in absolute EEG power robustly manifested in the alpha and beta frequency bands, and ii) a relative increase in the alpha power over the prefrontal brain regions against its reduction over the posterior regions. In the alpha band both effects are linked to the SZ symptoms measured with Positive and Negative Symptom Scales and to chronicity.
CONCLUSION
As alpha activity is related to regional deactivation, our findings support the concept of hypofrontality in SZ and expose the alpha rhythm as a sensitive indicator of it.
To reveal the EEG correlates of resting hypofrontality in schizophrenia (SZ).
METHOD
We analyzed the whole-head EEG topography in 14 patients compared to 14 matched controls by applying a new parameterization of the multichannel EEG. We used a combination of power measures tuned for regional surface mapping with power measures that allow evaluation of global effects.
RESULTS
The SZ-related EEG abnormalities include i) a global decrease in absolute EEG power robustly manifested in the alpha and beta frequency bands, and ii) a relative increase in the alpha power over the prefrontal brain regions against its reduction over the posterior regions. In the alpha band both effects are linked to the SZ symptoms measured with Positive and Negative Symptom Scales and to chronicity.
CONCLUSION
As alpha activity is related to regional deactivation, our findings support the concept of hypofrontality in SZ and expose the alpha rhythm as a sensitive indicator of it.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1111/j.1600-0447.2008.01227.x
- PMID 18636993
- Persistent URL
- https://sonar.ch/global/documents/181169
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