Human Brown Adipose Tissue: What We Have Learned So Far.
- Betz MJ Department of Endocrinology, Diabetes & Metabolism, University Hospital Basel, Basel, Switzerland.
- Enerbäck S Department of Medical and Clinical Genetics, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden sven.enerback@medgen.gu.se.
- 2015-06-09
Published in:
- Diabetes. - 2015
Adipose Tissue, Brown
Adult
Animals
DNA-Binding Proteins
Diabetes Mellitus
Energy Metabolism
Fluorodeoxyglucose F18
Glucose
Humans
Insulin Resistance
Obesity
Thermogenesis
Transcription Factors
English
Brown adipose tissue (BAT) is a unique tissue that is able to convert chemical energy directly into heat when activated by the sympathetic nervous system. While initially believed to be of relevance only in human newborns and infants, research during recent years provided unequivocal evidence of active BAT in human adults. Moreover, it has become clear that BAT plays an important role in insulin sensitivity in rodents and humans. This has opened the possibility for exciting new therapies for obesity and diabetes. This review summarizes the current state of research with a special focus on recent advances regarding BAT and insulin resistance in human adults. Additionally, we provide an outlook on possible future therapeutic uses of BAT in the treatment of obesity and diabetes.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.2337/db15-0146
- PMID 26050667
- Persistent URL
- https://sonar.ch/global/documents/18129
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