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Neutrophil-inspired propulsion in a combined acoustic and magnetic field.

  • Ahmed D Institute of Robotics and Intelligent Systems, ETH Zurich, Zurich, CH-8092, Switzerland. dahmed@ethz.ch.
  • Baasch T Institute of Mechanical Systems, ETH Zurich, Zurich, CH-8092, Switzerland.
  • Blondel N Institute of Robotics and Intelligent Systems, ETH Zurich, Zurich, CH-8092, Switzerland.
  • Läubli N Institute of Robotics and Intelligent Systems, ETH Zurich, Zurich, CH-8092, Switzerland.
  • Dual J Institute of Mechanical Systems, ETH Zurich, Zurich, CH-8092, Switzerland.
  • Nelson BJ Institute of Robotics and Intelligent Systems, ETH Zurich, Zurich, CH-8092, Switzerland. bnelson@ethz.ch.
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  • 2017-10-05
Published in:
  • Nature communications. - 2017
Acoustics
Dimethylpolysiloxanes
Drug Delivery Systems
Leukocyte Rolling
Magnetic Fields
Magnetics
Models, Cardiovascular
Motion
Neutrophils
Nylons
Sound
English Systems capable of precise motion in the vasculature can offer exciting possibilities for applications in targeted therapeutics and non-invasive surgery. So far, the majority of the work analysed propulsion in a two-dimensional setting with limited controllability near boundaries. Here we show bio-inspired rolling motion by introducing superparamagnetic particles in magnetic and acoustic fields, inspired by a neutrophil rolling on a wall. The particles self-assemble due to dipole-dipole interaction in the presence of a rotating magnetic field. The aggregate migrates towards the wall of the channel due to the radiation force of an acoustic field. By combining both fields, we achieved a rolling-type motion along the boundaries. The use of both acoustic and magnetic fields has matured in clinical settings. The combination of both fields is capable of overcoming the limitations encountered by single actuation techniques. We believe our method will have far-reaching implications in targeted therapeutics.Devising effective swimming and propulsion strategies in microenvironments is attractive for drug delivery applications. Here Ahmed et al. demonstrate a micropropulsion strategy in which a combination of magnetic and acoustic fields is used to assemble and propel colloidal particles along channel walls.
Language
  • English
Open access status
gold
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Persistent URL
https://sonar.ch/global/documents/181347
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