Application of response surface methodology to tailor the surface chemistry of electrospun chitosan-poly(ethylene oxide) fibers.
- Bösiger P Empa, Laboratory for Biomimetic Membranes and Textiles, Lerchenfeldstrasse 5, CH-9014 St. Gallen, Switzerland; University of Freiburg, Faculty of Environment & Natural Resources, Chair of Forest Botany, Bertoldstrasse 17, DE-79085 Freiburg, Germany.
- Richard IMT Empa, Laboratory for Biomimetic Membranes and Textiles, Lerchenfeldstrasse 5, CH-9014 St. Gallen, Switzerland; École européenne de Chimie, Polymères et Matériaux, Université de Strasbourg, 25 Rue Becquerel, FR-67087 Strasbourg, France.
- Le Gat L Empa, Laboratory for Biomimetic Membranes and Textiles, Lerchenfeldstrasse 5, CH-9014 St. Gallen, Switzerland; CBMN (UMR 5248, CNRS), 3BIO's Team, University of Bordeaux, Allée Geoffroy Saint-Hilaire, 33600 Pessac, France.
- Michen B Empa, Laboratory for Applied Wood Materials, Überlandstrasse 129, CH-8600 Dübendorf, Switzerland; Wood Materials Science, Institute for Building Materials, ETH Zürich, Stefano-Franscini-Platz 3, 8093 Zürich, Switzerland.
- Schubert M Empa, Laboratory for Applied Wood Materials, Überlandstrasse 129, CH-8600 Dübendorf, Switzerland.
- Rossi RM Empa, Laboratory for Biomimetic Membranes and Textiles, Lerchenfeldstrasse 5, CH-9014 St. Gallen, Switzerland.
- Fortunato G Empa, Laboratory for Biomimetic Membranes and Textiles, Lerchenfeldstrasse 5, CH-9014 St. Gallen, Switzerland. Electronic address: giuseppino.fortunato@empa.ch.
- 2018-02-20
Published in:
- Carbohydrate polymers. - 2018
English
Chitosan is a promising biocompatible polymer for regenerative engineering applications, but its processing remains challenging due to limited solubility and rigid crystalline structure. This work represents the development of electrospun chitosan/poly(ethylene oxide) blend nanofibrous membranes by means of a numerical analysis in order to identify and tailor the main influencing parameters with respect to accessible surface nitrogen functionalities which are of importance for the biological activity as well as for further functionalization. Depending on the solution composition, both gradient fibers and homogenous blended fiber structures could be obtained with surface nitrogen concentrations varying between 0 and 6.4%. Response surface methodology (RSM) revealed chitosan/poly(ethylene oxide) ratio and chitosan molecular weight as the main influencing factors with respect to accessible nitrogen surface atoms and respective concentrations. The model showed good adequacy hence providing a tool to tailor the surface properties of chitosan/poly(ethylene oxide) blends by addressing the amount of accessible chitosan.
- Language
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- English
- Open access status
- green
- Identifiers
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- DOI 10.1016/j.carbpol.2018.01.038
- PMID 29455969
- Persistent URL
- https://sonar.ch/global/documents/181469
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